2-tert-butyl-4-ethyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine

Base Information

Chemical Name:2-tert-butyl-4-ethyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine
CAS No.:861232-21-5
Molecular Formula:C₂₃H₂₅F₃N₂O₂
Molecular Weight:418.459
Hs Code.:

Synonyms:2-tert-butyl-4-ethyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine

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Chemical Property of 2-tert-butyl-4-ethyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine

Chemical Property:

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Technology Process of 2-tert-butyl-4-ethyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine

There total 4 articles about 2-tert-butyl-4-ethyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 861232-15-7
2-tert-butyl-5-chloro-4-ethyl-6-methoxy-8-nitroquinoline

: 861232-21-5
2-tert-butyl-4-ethyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / KOH / 12 h / 150 °C

2: 100 percent / H₂ / Raney nickel / 0.75 h / 2327.17 Torr

With potassium hydroxide; hydrogen; nickel;
DOI:10.1016/j.bmc.2005.04.034

Reference yield:

: 861232-12-4
2-tert-butyl-4-ethyl-6-methoxy-8-nitro-5-quinolinol

: 861232-21-5
2-tert-butyl-4-ethyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / POCl₃ / 2 h / 80 °C

2: 62 percent / KOH / 12 h / 150 °C

3: 100 percent / H₂ / Raney nickel / 0.75 h / 2327.17 Torr

With potassium hydroxide; hydrogen; trichlorophosphate; nickel;
DOI:10.1016/j.bmc.2005.04.034

Reference yield:

: 861232-09-9
2-tert-butyl-5,6-dimethoxy-4-ethyl-8-nitroquinoline

: 861232-21-5
2-tert-butyl-4-ethyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / HCl / 2 h / 100 °C

2: 100 percent / POCl₃ / 2 h / 80 °C

3: 62 percent / KOH / 12 h / 150 °C

4: 100 percent / H₂ / Raney nickel / 0.75 h / 2327.17 Torr

With hydrogenchloride; potassium hydroxide; hydrogen; trichlorophosphate; nickel;
DOI:10.1016/j.bmc.2005.04.034