6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol

Base Information

Chemical Name:6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol
CAS No.:1426082-26-9
Molecular Formula:C₂₈H₂₆N₄O₂
Molecular Weight:450.54
Hs Code.:

Synonyms:6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol

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Chemical Property of 6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol

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Technology Process of 6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol

There total 7 articles about 6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1251931-23-3
{2-[4-(4-bromo-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine

: 1426082-80-5
6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-naphthalen-1-ol

: 1426082-26-9
6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; for 2h; Reflux;
DOI:10.1016/j.bmc.2012.12.035

Reference yield:

: 1378382-85-4
(6-bromo-3,4-dihydro-naphthalen-1-yloxy)-triisopropyl-silane

: 1426082-26-9
6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 0.5 h / 80 °C

2: sodium hydroxide / methanol; water; 1-methyl-pyrrolidin-2-one / 1.5 h / 60 °C

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 90 °C

4: potassium carbonate; triphenylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; palladium diacetate; potassium carbonate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 4: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.12.035

Reference yield:

: 1378382-83-2
(6-bromo-naphthalen-1-yloxy)-triisopropyl-silane

: 1426082-26-9
6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; water; 1-methyl-pyrrolidin-2-one / 1.5 h / 60 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 90 °C

3: potassium carbonate; triphenylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.12.035