(S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline

Base Information

Chemical Name:(S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline
CAS No.:1332327-21-5
Molecular Formula:C₁₇H₂₁N₅O₃
Molecular Weight:343.385
Hs Code.:

Synonyms:(S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline

Chemical Property:

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Technology Process of (S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline

There total 1 articles about (S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6601-22-5
2,6-Dichloro-4-morpholino-1,3,5-triazine

: 1332327-21-5
(S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: -78 - 22 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 1 h / 140 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; 2.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.06.063

Reference yield: 53.0%

: 466694-47-3
4-amino-N-(2-(dimethylamino)ethyl)-N-methylbenzamide

: 32315-10-9
bis(trichloromethyl) carbonate

: 1332327-21-5
(S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline

: 1197166-07-6
N-[2-(dimethylamino)ethyl]-N-methyl-4-{[(4-{4-morpholin-4-yl-6-[(3S)-tetrahydrofuran-3-yloxy]-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzamide

Guidance literature:: bis(trichloromethyl) carbonate; (S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline; In tetrahydrofuran; at 25 ℃; for 0.0833333h;

With triethylamine; In tetrahydrofuran; for 1h;

4-amino-N-(2-(dimethylamino)ethyl)-N-methylbenzamide; In tetrahydrofuran; for 0.5h;
DOI:10.1016/j.bmcl.2011.06.063

Reference yield:

: 50534-08-2
(4-aminophenyl)(4-(dimethylamino)piperidin-1-yl)methanone

: 32315-10-9
bis(trichloromethyl) carbonate

: 1332327-21-5
(S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline

: 1332327-16-8
C₃₂H₄₀N₈O₅

Guidance literature:: bis(trichloromethyl) carbonate; (S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline; In tetrahydrofuran; at 25 ℃; for 0.0833333h;

With triethylamine; In tetrahydrofuran; for 1h;

(4-aminophenyl)(4-(dimethylamino)piperidin-1-yl)methanone; In tetrahydrofuran; for 0.5h;
DOI:10.1016/j.bmcl.2011.06.063