1-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-1H-pyrazole-4-carboxylic acid ethylester

Base Information

Chemical Name:1-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-1H-pyrazole-4-carboxylic acid ethylester
CAS No.:219664-26-3
Molecular Formula:C₁₆H₁₇FN₄O₄
Molecular Weight:348.334
Hs Code.:

Synonyms:1-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-1H-pyrazole-4-carboxylic acid ethylester

Suppliers and Price of 1-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-1H-pyrazole-4-carboxylic acid ethylester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-1H-pyrazole-4-carboxylic acid ethylester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-1H-pyrazole-4-carboxylic acid ethylester

There total 9 articles about 1-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-1H-pyrazole-4-carboxylic acid ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 219664-20-7
(S)-[3-[3-fluoro-4-(1H-4-carbethoxypyrazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl azide

: 219664-26-3
1-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-1H-pyrazole-4-carboxylic acid ethylester

Guidance literature:: With water; triphenylphosphine; In tetrahydrofuran; at 20 - 65 ℃;
DOI:10.1021/jm990373e

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 219664-26-3
1-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-1H-pyrazole-4-carboxylic acid ethylester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 94 percent / hydrazine hydrate; K₂CO₃ / acetonitrile

2.1: 65 percent / NaOAc / ethanol / Heating

3.1: 97 percent / H₂ / 10percent Pd/C / methanol / 3 h / 1034.32 Torr

4.1: 98 percent / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

5.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / -78 °C

5.2: 79 percent / tetrahydrofuran / -78 - 20 °C

6.1: 98 percent / NEt₃ / CH₂Cl₂ / 4 h / 20 °C

7.1: 93 percent / NaN₃ / dimethylformamide / 65 °C

8.1: 77 percent / triphenylphosphine; water / tetrahydrofuran / 20 - 65 °C

With sodium azide; water; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; hydrazine hydrate; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Substitution / 2.1: Condensation / 3.1: Reduction / 4.1: Acylation / 5.1: Metallation / 5.2: Ring cleavage / 6.1: mesylation / 7.1: Substitution / 8.1: Reduction;
DOI:10.1021/jm990373e

Reference yield:

: 127350-92-9
(2-fluoro-4-nitrophenyl)hydrazine

: 219664-26-3
1-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-1H-pyrazole-4-carboxylic acid ethylester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 65 percent / NaOAc / ethanol / Heating

2.1: 97 percent / H₂ / 10percent Pd/C / methanol / 3 h / 1034.32 Torr

3.1: 98 percent / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

4.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / -78 °C

4.2: 79 percent / tetrahydrofuran / -78 - 20 °C

5.1: 98 percent / NEt₃ / CH₂Cl₂ / 4 h / 20 °C

6.1: 93 percent / NaN₃ / dimethylformamide / 65 °C

7.1: 77 percent / triphenylphosphine; water / tetrahydrofuran / 20 - 65 °C

With sodium azide; water; hydrogen; sodium acetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Condensation / 2.1: Reduction / 3.1: Acylation / 4.1: Metallation / 4.2: Ring cleavage / 5.1: mesylation / 6.1: Substitution / 7.1: Reduction;
DOI:10.1021/jm990373e