tert-butyl cis-5-(4-bromophenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

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Chemical Name:tert-butyl cis-5-(4-bromophenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
CAS No.:1173179-67-3
Molecular Formula:C₁₇H₂₃BrN₂O₂
Molecular Weight:367.286
Hs Code.:

Synonyms:tert-butyl cis-5-(4-bromophenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

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Chemical Property of tert-butyl cis-5-(4-bromophenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

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Technology Process of tert-butyl cis-5-(4-bromophenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

There total 2 articles about tert-butyl cis-5-(4-bromophenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 589-87-7
1,4-bromoiodobenzene

: 250275-15-1,1256094-14-0
tert-butyl (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

: 1173179-67-3
tert-butyl cis-5-(4-bromophenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 90 ℃; for 16h;

Reference yield: 50.0%

: 106-37-6
1.4-dibromobenzene

: 250275-15-1,1256094-14-0
tert-butyl (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

: 1173179-67-3
tert-butyl cis-5-(4-bromophenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: tert-butyl (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 35 - 85 ℃; Inert atmosphere;

1.4-dibromobenzene; With sodium t-butanolate; In toluene; at 35 - 85 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm900249k

Reference yield: 64.0%

: 1173179-67-3
tert-butyl cis-5-(4-bromophenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

: 98-80-6
phenylboronic acid

: 1173179-73-1
t-butyl cis-2-biphenyl-4-yl-octahydro-pyrrolo[3,4-c]pyrrole-2-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In water; toluene; at 85 ℃; for 60h; Inert atmosphere;
DOI:10.1021/jm900249k