(E)-ethyl 3-(2-(3-chlorophenoxy)-4-(pyridin-3-ylmethoxy)phenyl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(2-(3-chlorophenoxy)-4-(pyridin-3-ylmethoxy)phenyl)acrylate
CAS No.:1446253-91-3
Molecular Formula:C₂₃H₂₀ClNO₄
Molecular Weight:409.869
Hs Code.:

Synonyms:(E)-ethyl 3-(2-(3-chlorophenoxy)-4-(pyridin-3-ylmethoxy)phenyl)acrylate

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Chemical Property of (E)-ethyl 3-(2-(3-chlorophenoxy)-4-(pyridin-3-ylmethoxy)phenyl)acrylate

Chemical Property:

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Technology Process of (E)-ethyl 3-(2-(3-chlorophenoxy)-4-(pyridin-3-ylmethoxy)phenyl)acrylate

There total 5 articles about (E)-ethyl 3-(2-(3-chlorophenoxy)-4-(pyridin-3-ylmethoxy)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 100-55-0
3-hydroxymethylpyridin

: 1446253-90-2
(E)-ethyl 3-(2-(3-chlorophenoxy)-4-hydroxyphenyl)acrylate

: 1446253-91-3
(E)-ethyl 3-(2-(3-chlorophenoxy)-4-(pyridin-3-ylmethoxy)phenyl)acrylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 108-43-0
3-monochlorophenol

: 1446253-91-3
(E)-ethyl 3-(2-(3-chlorophenoxy)-4-(pyridin-3-ylmethoxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 3 h / 120 °C / Inert atmosphere

2: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 65 h / 20 °C

3: boron tribromide / dichloromethane / -70 - 20 °C / Inert atmosphere

4: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium chloride; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 331-64-6
2-fluoro-4-methoxy-benzaldehyde

: 1446253-91-3
(E)-ethyl 3-(2-(3-chlorophenoxy)-4-(pyridin-3-ylmethoxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 3 h / 120 °C / Inert atmosphere

2: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 65 h / 20 °C

3: boron tribromide / dichloromethane / -70 - 20 °C / Inert atmosphere

4: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium chloride; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile;