tert-Butyl 4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate
CAS No.:1004304-10-2
Molecular Formula:C₁₆H₂₄FN₃O₂
Molecular Weight:309.384
Hs Code.:
DSSTox Substance ID:DTXSID20693175
Mol file:1004304-10-2.mol

Synonyms:1004304-10-2;tert-Butyl 4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate;tert-Butyl 4-(2-amino-4-fluorophenylamino)piperidine-1-carboxylate;tert-butyl 4-(2-amino-4-fluoroanilino)piperidine-1-carboxylate;SCHEMBL22724870;DTXSID20693175;MFCD17014093;AB22238;KS-5566;tert-Butyl4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate

Suppliers and Price of tert-Butyl 4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate 95+%
1g
$ 339.00

Chemenu
tert-butyl4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate 95%
1g
$ 320.00

Alichem
tert-Butyl4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate
1g
$ 400.00

Total 3 raw suppliers

Chemical Property of tert-Butyl 4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate

Chemical Property:

Boiling Point:443.3±45.0 °C(Predicted)
PKA:4.74±0.11(Predicted)
Density:1?+-.0.06 g/cm3(Predicted)
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:309.18525518
Heavy Atom Count:22
Complexity:378

Purity/Quality:

95+% ^*data from raw suppliers

tert-Butyl4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)NC2=C(C=C(C=C2)F)N

Technology Process of tert-Butyl 4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate

There total 4 articles about tert-Butyl 4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

: tert-butyl 4-((4-fluoro-2-nitrophenyl)amino)piperidine-1-carboxylate

: 1004304-10-2
tert-butyl 4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h;

Reference yield: 71.0%

: 367-31-7
4-fluoro-1,2-phenylenediamine

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1004304-10-2
tert-butyl 4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate

: 1429415-83-7
C₂₆H₄₁FN₄O₄

Guidance literature:: 4-fluoro-1,2-phenylenediamine; N-tert-butyloxycarbonylpiperidin-4-one; With acetic acid; In dichloromethane; at 0 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1080/00397911.2012.670740

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1004304-10-2
tert-butyl 4-((2-amino-4-fluorophenyl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 20 °C / Inert atmosphere

2: hydrazine hydrate / water; ethanol / 0.17 h / 45 °C

With potassium carbonate; hydrazine hydrate; In ethanol; water; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.8b01136