N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine

Base Information

Chemical Name:N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine
CAS No.:256497-25-3
Molecular Formula:C₂₆H₄₁Cl₂N₃O₂
Molecular Weight:498.536
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine

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Chemical Property of N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine

Chemical Property:

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Technology Process of N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine

There total 4 articles about N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 256497-25-3
N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / CH₂Cl₂ / 20 °C

2: 93 percent / NEt₃ / CH₂Cl₂ / 2 h / 20 °C

3: 100 percent / KI / acetone / 16 h / Heating

4: K₂CO₃ / acetonitrile / 18 h / 80 °C

With potassium carbonate; triethylamine; potassium iodide; In dichloromethane; acetone; acetonitrile; 1: Substitution / 2: Esterification / 3: Substitution / 4: Substitution;
DOI:10.1016/S0223-5234(99)00210-X

Reference yield:

: 182621-51-8
(+)-3-(3,4-dichlorophenyl)-3-(3-hydroxypropyl)-piperidine

: 256497-25-3
N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / CH₂Cl₂ / 20 °C

2: 93 percent / NEt₃ / CH₂Cl₂ / 2 h / 20 °C

3: 100 percent / KI / acetone / 16 h / Heating

4: K₂CO₃ / acetonitrile / 18 h / 80 °C

With potassium carbonate; triethylamine; potassium iodide; In dichloromethane; acetone; acetonitrile; 1: Substitution / 2: Esterification / 3: Substitution / 4: Substitution;
DOI:10.1016/S0223-5234(99)00210-X

Reference yield:

: 172734-62-2,172734-66-6
N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-(3-hydroxypropyl)piperidine

: 256497-25-3
N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / NEt₃ / CH₂Cl₂ / 2 h / 20 °C

2: 100 percent / KI / acetone / 16 h / Heating

3: K₂CO₃ / acetonitrile / 18 h / 80 °C

With potassium carbonate; triethylamine; potassium iodide; In dichloromethane; acetone; acetonitrile; 1: Esterification / 2: Substitution / 3: Substitution;
DOI:10.1016/S0223-5234(99)00210-X