(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-(4-fluoro-2-trifluoromethyl-phenyl)-methanone

Base Information

• Chemical Name: (6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-(4-fluoro-2-trifluoromethyl-phenyl)-methanone
• CAS No.: 220603-08-7
• Molecular Formula: C₂₀H₁₃F₄N₃O
• Molecular Weight: 387.336
• Mol file: 220603-08-7.mol

Synonyms:(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-(4-fluoro-2-trifluoromethyl-phenyl)-methanone

Chemical Property of (6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-(4-fluoro-2-trifluoromethyl-phenyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-(4-fluoro-2-trifluoromethyl-phenyl)-methanone

There total 10 articles about (6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-(4-fluoro-2-trifluoromethyl-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.1%

6,11-dihydro-5H-pyrido{2,3-b][1,5]benzodiazepine (16287-36-8) + 2-trifluoromethyl-4-fluorobenzoyl chloride (189807-21-4) → (6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-(4-fluoro-2-trifluoromethyl-phenyl)-methanone (220603-08-7)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1.25h;

Reference yield: 33.1%

ethyl acetate n-hexane + 6,11-dihydro-5H-pyrido{2,3-b][1,5]benzodiazepine (16287-36-8) + 2-trifluoromethyl-4-fluorobenzoyl chloride (189807-21-4) → (6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-(4-fluoro-2-trifluoromethyl-phenyl)-methanone (220603-08-7)

Guidance literature:

With potassium carbonate; In N-methyl-acetamide; dichloromethane;

Reference yield:

4-fluoro-2-trifluoromethylbenzoic acid (141179-72-8) → (6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-(4-fluoro-2-trifluoromethyl-phenyl)-methanone (220603-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / Heating

2: K₂CO₃

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.bmcl.2005.10.107

upstream raw materials:

N,N-dimethyl-formamide

6,11-dihydro-5H-pyrido{2,3-b][1,5]benzodiazepine

2-trifluoromethyl-4-fluorobenzoyl chloride

2-chloronicotinic acid

Downstream raw materials:

[4-(5-methyl-1H-pyrazol-1-yl)-2-(trifluoromethyl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

[4-(3-methyl-1H-pyrazol-1-yl)-2-(trifluoromethyl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

[2-(Trifluoromethyl)-4-(3-trifluoromethyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

[4-(3-tert-butyl-1H-pyrazol-1-yl)-2-(trifluoromethyl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone