4-nitro-N-((6-oxo-2-phenyltetrahydro-2H-pyran-2-yl)methyl)benzenesulfonamide

Base Information

Chemical Name:4-nitro-N-((6-oxo-2-phenyltetrahydro-2H-pyran-2-yl)methyl)benzenesulfonamide
CAS No.:1338575-97-5
Molecular Formula:C₁₈H₁₈N₂O₆S
Molecular Weight:390.417
Hs Code.:

Synonyms:4-nitro-N-((6-oxo-2-phenyltetrahydro-2H-pyran-2-yl)methyl)benzenesulfonamide

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Chemical Property of 4-nitro-N-((6-oxo-2-phenyltetrahydro-2H-pyran-2-yl)methyl)benzenesulfonamide

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Technology Process of 4-nitro-N-((6-oxo-2-phenyltetrahydro-2H-pyran-2-yl)methyl)benzenesulfonamide

There total 4 articles about 4-nitro-N-((6-oxo-2-phenyltetrahydro-2H-pyran-2-yl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1338575-91-9
tert-butyl 5-phenylhex-5-enoate

: 6325-93-5
p-nitrobenzenesulfonamide

: 1338575-97-5
4-nitro-N-((6-oxo-2-phenyltetrahydro-2H-pyran-2-yl)methyl)benzenesulfonamide

Guidance literature:: tert-butyl 5-phenylhex-5-enoate; With tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; In acetonitrile; at 20 ℃; for 0.166667h; Molecular sieve;

p-nitrobenzenesulfonamide; With iodosylbenzene; In acetonitrile; at 20 ℃; for 48h;
DOI:10.1021/ol202436a

Reference yield:

: 98-80-6
phenylboronic acid

: 1338575-97-5
4-nitro-N-((6-oxo-2-phenyltetrahydro-2H-pyran-2-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid / 1,4-dioxane / 15.25 h / 20 - 80 °C / Inert atmosphere

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20.25 h / 0 - 20 °C

3.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / acetonitrile / 0.17 h / 20 °C / Molecular sieve

3.2: 48 h / 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; acetic acid; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/ol202436a

Reference yield:

: 174708-24-8
5-phenyl-5-pentenoic acid

: 1338575-97-5
4-nitro-N-((6-oxo-2-phenyltetrahydro-2H-pyran-2-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20.25 h / 0 - 20 °C

2.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / acetonitrile / 0.17 h / 20 °C / Molecular sieve

2.2: 48 h / 20 °C

With dmap; tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;
DOI:10.1021/ol202436a