(3S)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Base Information

• Chemical Name: (3S)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• CAS No.: 236429-63-3
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.217
• DSSTox Substance ID: DTXSID60573568
• Mol file: 236429-63-3.mol

Synonyms:236429-63-3;(S)-7-amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;(3S)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;DTXSID60573568;3-Isoquinolinecarboxylicacid,7-amino-1,2,3,4-tetrahydro-,(3S)-(9CI)

Chemical Property of (3S)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Chemical Property:

• PSA: 75.35000
• LogP: 1.27770
• XLogP3: -2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 192.089877630
• Heavy Atom Count: 14
• Complexity: 232

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(NCC2=C1C=CC(=C2)N)C(=O)O
• Isomeric SMILES: C1[C@H](NCC2=C1C=CC(=C2)N)C(=O)O

Technology Process of (3S)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

There total 2 articles about (3S)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-7-nitro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (77141-07-2,233272-36-1) → 7-amino-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (236429-63-3,754170-16-6,756803-94-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(01)00491-9

Reference yield:

L-Tic-OH (74163-81-8) → 7-amino-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (236429-63-3,754170-16-6,756803-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / HNO₃; H₂SO₄ / 3.5 h / -10 °C

2: 98 percent / H₂ / Pd/C / methanol / 2 h / 20 °C

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In methanol;

DOI:10.1016/S0040-4039(01)00491-9

upstream raw materials:

(S)-7-nitro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

L-Tic-OH

Refernces