4′-[(S)-2-(hexahydro-2,5-methanopentalen-3a-ylamino)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-5-yl]-biphenyl-3-carboxylic acid

Base Information

• Chemical Name: 4′-[(S)-2-(hexahydro-2,5-methanopentalen-3a-ylamino)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-5-yl]-biphenyl-3-carboxylic acid
• CAS No.: 1397322-07-4
• Molecular Formula: C₂₇H₃₀N₂O₅S
• Molecular Weight: 494.612

Synonyms:4′-[(S)-2-(hexahydro-2,5-methanopentalen-3a-ylamino)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-5-yl]-biphenyl-3-carboxylic acid

Chemical Property of 4′-[(S)-2-(hexahydro-2,5-methanopentalen-3a-ylamino)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-5-yl]-biphenyl-3-carboxylic acid

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Technology Process of 4′-[(S)-2-(hexahydro-2,5-methanopentalen-3a-ylamino)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-5-yl]-biphenyl-3-carboxylic acid

There total 2 articles about 4′-[(S)-2-(hexahydro-2,5-methanopentalen-3a-ylamino)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-5-yl]-biphenyl-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H25BrN2O3S (1397322-19-8) + 3-Carboxyphenylboronic acid (25487-66-5) → 4′-[(S)-2-(hexahydro-2,5-methanopentalen-3a-ylamino)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4λ6-[1,4,3]oxathiazin-5-yl]-biphenyl-3-carboxylic acid (1397322-07-4)

Guidance literature:

With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; caesium carbonate; In 1,4-dioxane; water; at 62 ℃; for 0.666667h; Inert atmosphere;

Reference yield:

tricyclo[3.3.1.03,7]nonan-3-amine (28224-43-3) + (S)-5-(4-bromophenyl)-2-methoxy-6,6-dimethyl-5,6-dihydro-[1,4,3]oxathiazine 4,4-dioxide (1397322-25-6) → 4′-[(S)-2-(hexahydro-2,5-methanopentalen-3a-ylamino)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4λ6-[1,4,3]oxathiazin-5-yl]-biphenyl-3-carboxylic acid (1397322-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; caesium carbonate / water; 1,4-dioxane / 0.67 h / 62 °C / Inert atmosphere

With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; caesium carbonate; In 1,4-dioxane; dichloromethane; water;

upstream raw materials:

C₂₀H₂₅BrN₂O₃S

3-Carboxyphenylboronic acid

tricyclo[3.3.1.0^3,7]nonan-3-amine

(S)-5-(4-bromophenyl)-2-methoxy-6,6-dimethyl-5,6-dihydro-[1,4,3]oxathiazine 4,4-dioxide

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