1-[(3S,3aR,4S,6R,7aR)-3-(4-Methoxymethoxymethyl-phenoxy)-4,6,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl]-ethanone

Base Information

Chemical Name:1-[(3S,3aR,4S,6R,7aR)-3-(4-Methoxymethoxymethyl-phenoxy)-4,6,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl]-ethanone
CAS No.:864151-99-5
Molecular Formula:C₂₃H₃₂O₄
Molecular Weight:372.505
Hs Code.:

Synonyms:1-[(3S,3aR,4S,6R,7aR)-3-(4-Methoxymethoxymethyl-phenoxy)-4,6,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl]-ethanone

Suppliers and Price of 1-[(3S,3aR,4S,6R,7aR)-3-(4-Methoxymethoxymethyl-phenoxy)-4,6,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl]-ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(3S,3aR,4S,6R,7aR)-3-(4-Methoxymethoxymethyl-phenoxy)-4,6,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(3S,3aR,4S,6R,7aR)-3-(4-Methoxymethoxymethyl-phenoxy)-4,6,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl]-ethanone

There total 11 articles about 1-[(3S,3aR,4S,6R,7aR)-3-(4-Methoxymethoxymethyl-phenoxy)-4,6,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 864151-98-4
(1S,3aR,5R,7S,7aR)-3a,5,7-Trimethyl-3-(2-methyl-[1,3]dithian-2-yl)-3a,4,5,6,7,7a-hexahydro-1H-inden-1-ol

: 864151-99-5
1-[(3S,3aR,4S,6R,7aR)-3-(4-Methoxymethoxymethyl-phenoxy)-4,6,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl]-ethanone

Guidance literature:: (1S,3aR,5R,7S,7aR)-3a,5,7-Trimethyl-3-(2-methyl-[1,3]dithian-2-yl)-3a,4,5,6,7,7a-hexahydro-1H-inden-1-ol; η⁶-4-FC6H4CH2OMOM-Cr(CO)3; With sodium hydride; In tetrahydrofuran; for 7h; Heating;

With ammonium cerium(IV) nitrate; sodium hydrogencarbonate; In acetonitrile; at -23 ℃; for 0.333333h;

With Dess-Martin periodane; In dichloromethane; acetonitrile; at 20 ℃; for 39h;
DOI:10.1055/s-2005-871549

Reference yield:

: 864151-95-1
(1R,3aR,4S,6R,7aR)-4,6,7a-Trimethyl-octahydro-inden-1-ol

: 864151-99-5
1-[(3S,3aR,4S,6R,7aR)-3-(4-Methoxymethoxymethyl-phenoxy)-4,6,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: 93 percent / (COCl)2; DMSO; Et₃N / 1 h / -78 - 0 °C

2.1: LDA / tetrahydrofuran / 3 h / -78 °C

2.2: tetrahydrofuran

3.1: allyl carbonate / Pd(OAc)2 / acetonitrile / Heating

4.1: 97 percent / tetrahydrofuran / 5 h / -78 - -23 °C

5.1: 77 percent / aq. H₂SO₄ / tetrahydrofuran / 24 h / 0 - 20 °C

6.1: NaH / tetrahydrofuran / 7 h / Heating

6.2: CAN; NaHCO₃ / acetonitrile / 0.33 h / -23 °C

6.3: 70 percent / aq. Dess-Martin periodinane / acetonitrile; CH₂Cl₂ / 39 h / 20 °C

With oxalyl dichloride; diallylcarbonate; sulfuric acid; sodium hydride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; palladium diacetate; In tetrahydrofuran; acetonitrile; 1.1: Swern oxidation;
DOI:10.1055/s-2005-871549

Reference yield:

: 864151-96-2
(3aR,4S,6R,7aR)-4,6,7a-Trimethyl-octahydro-inden-1-one

: 864151-99-5
1-[(3S,3aR,4S,6R,7aR)-3-(4-Methoxymethoxymethyl-phenoxy)-4,6,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran / 3 h / -78 °C

1.2: tetrahydrofuran

2.1: allyl carbonate / Pd(OAc)2 / acetonitrile / Heating

3.1: 97 percent / tetrahydrofuran / 5 h / -78 - -23 °C

4.1: 77 percent / aq. H₂SO₄ / tetrahydrofuran / 24 h / 0 - 20 °C

5.1: NaH / tetrahydrofuran / 7 h / Heating

5.2: CAN; NaHCO₃ / acetonitrile / 0.33 h / -23 °C

5.3: 70 percent / aq. Dess-Martin periodinane / acetonitrile; CH₂Cl₂ / 39 h / 20 °C

With diallylcarbonate; sulfuric acid; sodium hydride; lithium diisopropyl amide; palladium diacetate; In tetrahydrofuran; acetonitrile;
DOI:10.1055/s-2005-871549