1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(6-nitroquinazolin-4-ylamino)phenyl)urea

Base Information

• Chemical Name: 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(6-nitroquinazolin-4-ylamino)phenyl)urea
• CAS No.: 1163731-03-0
• Molecular Formula: C₂₉H₂₈N₈O₃
• Molecular Weight: 536.593

Synonyms:1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(6-nitroquinazolin-4-ylamino)phenyl)urea

Chemical Property of 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(6-nitroquinazolin-4-ylamino)phenyl)urea

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Technology Process of 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(6-nitroquinazolin-4-ylamino)phenyl)urea

There total 1 articles about 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(6-nitroquinazolin-4-ylamino)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-6-nitro-quinazoline (19815-16-8) + 1-(3-aminophenyl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea hydrochloride (1163730-93-5) → 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(6-nitroquinazolin-4-ylamino)phenyl)urea (1163731-03-0)

Guidance literature:

1-(3-aminophenyl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.166667h;

4-chloro-6-nitro-quinazoline; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/ja902010p

Reference yield: 72.0%

1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(6-nitroquinazolin-4-ylamino)phenyl)urea (1163731-03-0) → 1-(3-(6-aminoquinazolin-4-ylamino)phenyl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea (1163731-05-2)

Guidance literature:

With palladium on activated charcoal; ammonium formate; In ethanol; at 90 ℃; for 3h;

DOI:10.1021/ja902010p

upstream raw materials:

4-chloro-6-nitro-quinazoline

1-(3-aminophenyl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea hydrochloride

Downstream raw materials:

1-(3-(6-aminoquinazolin-4-ylamino)phenyl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea

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