2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone

Base Information

Chemical Name:2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone
CAS No.:1190970-06-9
Molecular Formula:C₃₀H₄₃N₃O₅S₂
Molecular Weight:589.821
Hs Code.:

Synonyms:2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone

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Chemical Property of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone

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Technology Process of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone

There total 10 articles about 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1018827-17-2
2-((1-(4-methoxy-2, 6-dimethylphenyl-sulfonyl)piperidin-2-yl)methoxy) acetic acid

: 1190971-13-1
2-(piperidin-1-ylmethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

: 1190970-06-9
2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 165947-56-8
5-tert-butoxycarbonyl-2-hydroxymethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

: 1190970-06-9
2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hypochlorite; sodium hydrogencarbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 0 - 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With sodium hypochlorite; 1-hydroxy-7-aza-benzotriazole; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1190971-27-7
5-benzyl 2-ethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate

: 1190970-06-9
2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; triethylamine / palladium 10% on activated carbon / ethanol / 4654.46 Torr

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2.2: Saturated solution

3.1: sodium hypochlorite; sodium hydrogencarbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 0 - 20 °C

4.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With sodium hypochlorite; lithium aluminium tetrahydride; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;