(E)-(tert-butyldimethylsilanyloxy)-4-methyl-5-iodo-6-(para-methoxybenzyloxy)-hex-4-ene

Base Information

Chemical Name:(E)-(tert-butyldimethylsilanyloxy)-4-methyl-5-iodo-6-(para-methoxybenzyloxy)-hex-4-ene
CAS No.:1283712-83-3
Molecular Formula:C₂₁H₃₅IO₃Si
Molecular Weight:490.497
Hs Code.:

Synonyms:(E)-(tert-butyldimethylsilanyloxy)-4-methyl-5-iodo-6-(para-methoxybenzyloxy)-hex-4-ene

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Chemical Property of (E)-(tert-butyldimethylsilanyloxy)-4-methyl-5-iodo-6-(para-methoxybenzyloxy)-hex-4-ene

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Technology Process of (E)-(tert-butyldimethylsilanyloxy)-4-methyl-5-iodo-6-(para-methoxybenzyloxy)-hex-4-ene

There total 6 articles about (E)-(tert-butyldimethylsilanyloxy)-4-methyl-5-iodo-6-(para-methoxybenzyloxy)-hex-4-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1283712-95-7
(E)-6-(tert-butyldimethylsilanyloxy)-2-iodo-3-methylhex-2-en-1-ol

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 1283712-83-3
(E)-(tert-butyldimethylsilanyloxy)-4-methyl-5-iodo-6-(para-methoxybenzyloxy)-hex-4-ene

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; cyclohexane; at 25 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c1ob05448a

Reference yield:

: 1283712-82-2
(E)-4,8-dimethyl-5-iodo-(tert-butyldimethylsilanyloxy)-4-hexenoate

: 1283712-83-3
(E)-(tert-butyldimethylsilanyloxy)-4-methyl-5-iodo-6-(para-methoxybenzyloxy)-hex-4-ene

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / hexane; dichloromethane / 3 h / -78 °C / Inert atmosphere

2: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 4 h / 25 °C / Inert atmosphere

With trifluorormethanesulfonic acid; diisobutylaluminium hydride; In hexane; dichloromethane; cyclohexane;
DOI:10.1039/c1ob05448a

Reference yield:

: 145383-97-7
methyl 6–(tert–butyldimethylsilyloxy)hex–2–ynoate

: 1283712-83-3
(E)-(tert-butyldimethylsilanyloxy)-4-methyl-5-iodo-6-(para-methoxybenzyloxy)-hex-4-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide / tetrahydrofuran; diethyl ether / 0 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

1.3: 3 h / -78 - 0 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / hexane; dichloromethane / 3 h / -78 °C / Inert atmosphere

3.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 4 h / 25 °C / Inert atmosphere

With copper(l) iodide; trifluorormethanesulfonic acid; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; cyclohexane;
DOI:10.1039/c1ob05448a