1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-((2-phenylethylamino)carbonyloxy)ethyl]azetidin-2-one

Base Information

Chemical Name:1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-((2-phenylethylamino)carbonyloxy)ethyl]azetidin-2-one
CAS No.:1426255-56-2
Molecular Formula:C₁₈H₂₃N₃O₄
Molecular Weight:345.398
Hs Code.:

Synonyms:1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-((2-phenylethylamino)carbonyloxy)ethyl]azetidin-2-one

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Chemical Property of 1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-((2-phenylethylamino)carbonyloxy)ethyl]azetidin-2-one

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Technology Process of 1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-((2-phenylethylamino)carbonyloxy)ethyl]azetidin-2-one

There total 3 articles about 1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-((2-phenylethylamino)carbonyloxy)ethyl]azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1943-82-4
phenethyl isocyanate

: 1426255-41-5
1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-hydroxyethyl]azetidin-2-one

: 1426255-56-2
1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-((2-phenylethylamino)carbonyloxy)ethyl]azetidin-2-one

Guidance literature:: With C₁₆H₃₅O₄Ti^(1-); In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.11.035

Reference yield:

: 109323-90-2
(1'R,3S)-3-<1'-<(tert-butyldimethylsilyl)oxy>ethyl>azetidin-2-one

: 1426255-56-2
1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-((2-phenylethylamino)carbonyloxy)ethyl]azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; acetic acid / acetonitrile; water / 3.5 h / -5 - 0 °C / Inert atmosphere

3.1: C₁₆H₃₅O₄Ti^(1-) / dichloromethane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; C₁₆H₃₅O₄Ti^(1-); acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2012.11.035

Reference yield:

: 1426255-37-9
1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

: 1426255-56-2
1-(propyl-3-enamino)carbonyl-(3S)-3-[(1R)-((2-phenylethylamino)carbonyloxy)ethyl]azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; acetic acid / acetonitrile; water / 3.5 h / -5 - 0 °C / Inert atmosphere

2: C₁₆H₃₅O₄Ti^(1-) / dichloromethane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; C₁₆H₃₅O₄Ti^(1-); acetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2012.11.035