Benzenemethanamine, alpha-ethyl-4-methoxy-, (alphaR)- (9CI)

Base Information

• Chemical Name: Benzenemethanamine, alpha-ethyl-4-methoxy-, (alphaR)- (9CI)
• CAS No.: 235083-55-3
• Molecular Formula: C10H15 N O
• Molecular Weight: 165.235
• Mol file: 235083-55-3.mol

Synonyms:(+)-1-(4-Methoxyphenyl)propylamine

Chemical Property of Benzenemethanamine, alpha-ethyl-4-methoxy-, (alphaR)- (9CI)

Chemical Property:

• PSA: 35.25000
• LogP: 2.80530

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-(4-Methoxyphenyl)propan-1-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, alpha-ethyl-4-methoxy-, (alphaR)- (9CI)

There total 9 articles about Benzenemethanamine, alpha-ethyl-4-methoxy-, (alphaR)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.2%

(2R)-2-<2-<(1R)-1-(4-methoxyphenyl)propyl>-1-methylhydrazino>butan-1-ol → (R)-1-(4-methoxyphenyl)propan-1-amine (235083-55-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 110 - 120 ℃; for 5h; under 4500.36 Torr;

DOI:10.1016/S0957-4166(99)00146-9

Reference yield:

4-Methoxypropiophenone (121-97-1) → (R)-1-(4-methoxyphenyl)propan-1-amine (235083-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 87 percent / hydroxylamine hydrochloride; K₂CO₃ / ethanol / Heating

2.1: NaH / dimethylformamide / 0 °C

2.2: 84 percent / dimethylformamide / 0 - 20 °C

3.1: BH₃*THF; (S)-proline (R)-1,1'-bi(2-naphthyl)dioxyboryl ester / tetrahydrofuran / 48 h / 0 - 5 °C

3.2: aq. HCl / tetrahydrofuran

With borane-THF; (S)-proline (R)-1,1'-bi(2-naphthyl)dioxyboryl ester; hydroxylamine hydrochloride; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jo060123n

Reference yield:

1-(4-methoxylphenyl)-2-propen-1-ol (51410-44-7) → (R)-1-(4-methoxyphenyl)propan-1-amine (235083-55-3)

Guidance literature:

1-(4-methoxylphenyl)-2-propen-1-ol; With C₁₇H₂₂Cl₂N₂Ru; isopropylamine; In aq. phosphate buffer; at 50 ℃; for 12h; pH=8.5; Inert atmosphere;

With pyridoxal 5'-phosphate; ω-transaminase ATA-024; isopropylamine; In aq. phosphate buffer; dimethyl sulfoxide; at 35 ℃; for 24h; pH=8.5; Enzymatic reaction;

DOI:10.1039/c5cc03298a

upstream raw materials:

1-(4-methoxyphenyl)propan-1-amine

N-[1-(4-methoxyphenyl)propyl]-P,P-diphenylphosphinic amide

1-(4-methoxyphenyl)propan-1-one oxime

4-Methoxypropiophenone

Downstream raw materials:

C₁₇H₁₉NO₂