3-[(1R)-1-(2-bromo-3-methylphenyl)ethyl]-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide

Base Information

Chemical Name:3-[(1R)-1-(2-bromo-3-methylphenyl)ethyl]-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide
CAS No.:1607484-62-7
Molecular Formula:C₂₁H₁₆BrF₂N₃O₄S
Molecular Weight:524.343
Hs Code.:

Synonyms:3-[(1R)-1-(2-bromo-3-methylphenyl)ethyl]-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide

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Chemical Property of 3-[(1R)-1-(2-bromo-3-methylphenyl)ethyl]-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide

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Technology Process of 3-[(1R)-1-(2-bromo-3-methylphenyl)ethyl]-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide

There total 2 articles about 3-[(1R)-1-(2-bromo-3-methylphenyl)ethyl]-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944268-58-0
1-(2-bromo-3-methylphenyl)ethan-1-one

: 1607484-62-7
3-[(1R)-1-(2-bromo-3-methylphenyl)ethyl]-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-THF / tetrahydrofuran; toluene / 1 h / 20 °C

2: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With borane-THF; triphenylphosphine; trifluoroacetic acid; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1607486-12-3
(S)-1-(2-bromo-3-methylphenyl)ethanol

: 1607484-62-7
3-[(1R)-1-(2-bromo-3-methylphenyl)ethyl]-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1314538-55-0
potassium tert-butyl N-[(trifluorolambda-4-boranyl)methyl]carbamate

: 1607484-62-7
3-[(1R)-1-(2-bromo-3-methylphenyl)ethyl]-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide

: 76-05-1
trifluoroacetic acid

: 3-{(1R)-1-[2-(aminomethyl)-3-methylphenyl]ethyl}-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide trifluoroacetic acid salt

Guidance literature:: potassium tert-butyl N-[(trifluorolambda-4-boranyl)methyl]carbamate; 3-[(1R)-1-(2-bromo-3-methylphenyl)ethyl]-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 90 ℃;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;