Technology Process of O6-Benzyl-N2,3-etheno-3',5'-O-(1,1,3,3-tetraisopropyldisiloxa-1,3-diyl)guanosine
There total 4 articles about O6-Benzyl-N2,3-etheno-3',5'-O-(1,1,3,3-tetraisopropyldisiloxa-1,3-diyl)guanosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 48.3 percent / triphenylphosphine, diethyl azodicarboxylate / dioxane / 48 h / 24 °C
2: 93 percent / NaOH / methanol / 48 h / Ambient temperature
3: 47.9 percent / aq. sodium acetate, aq. acetic acid, KI / ethanol; H2O / 30 h / 37 - 40 °C / pH=4.5
4: 89 percent / pyridine / 12 h
With
pyridine; sodium hydroxide; sodium acetate; acetic acid; triphenylphosphine; potassium iodide; diethylazodicarboxylate;
In
1,4-dioxane; methanol; ethanol; water;
DOI:10.1021/jo00061a033
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 47.9 percent / aq. sodium acetate, aq. acetic acid, KI / ethanol; H2O / 30 h / 37 - 40 °C / pH=4.5
2: 89 percent / pyridine / 12 h
With
pyridine; sodium acetate; acetic acid; potassium iodide;
In
ethanol; water;
DOI:10.1021/jo00061a033
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 93 percent / NaOH / methanol / 48 h / Ambient temperature
2: 47.9 percent / aq. sodium acetate, aq. acetic acid, KI / ethanol; H2O / 30 h / 37 - 40 °C / pH=4.5
3: 89 percent / pyridine / 12 h
With
pyridine; sodium hydroxide; sodium acetate; acetic acid; potassium iodide;
In
methanol; ethanol; water;
DOI:10.1021/jo00061a033