ethyl 2-[4-[(4R)-benzyloxy-2-pyrrolidinyl]-1-piperazinyl]-2-methylpropionate

Base Information

Chemical Name:ethyl 2-[4-[(4R)-benzyloxy-2-pyrrolidinyl]-1-piperazinyl]-2-methylpropionate
CAS No.:886447-26-3
Molecular Formula:C₂₂H₃₃N₃O₄
Molecular Weight:403.522
Hs Code.:

Synonyms:ethyl 2-[4-[(4R)-benzyloxy-2-pyrrolidinyl]-1-piperazinyl]-2-methylpropionate

Suppliers and Price of ethyl 2-[4-[(4R)-benzyloxy-2-pyrrolidinyl]-1-piperazinyl]-2-methylpropionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-[4-[(4R)-benzyloxy-2-pyrrolidinyl]-1-piperazinyl]-2-methylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-[4-[(4R)-benzyloxy-2-pyrrolidinyl]-1-piperazinyl]-2-methylpropionate

There total 3 articles about ethyl 2-[4-[(4R)-benzyloxy-2-pyrrolidinyl]-1-piperazinyl]-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 886448-00-6
ethyl 2-[4-[(4R)-benzyloxy-1-tert-butoxycarbonyl-(2S)-pyrrolidinylcarbonyl]-1-piperazinyl]-2-methylpropionate

: 886447-26-3
ethyl 2-[4-[(4R)-benzyloxy-2-pyrrolidinyl]-1-piperazinyl]-2-methylpropionate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2005.11.058

Reference yield:

: 886447-23-0
ethyl 2-(1-piperazinyl)-2-methylpropionate

: 886447-26-3
ethyl 2-[4-[(4R)-benzyloxy-2-pyrrolidinyl]-1-piperazinyl]-2-methylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl salt; HOBt; Et₃N / dimethylformamide / 12 h / 20 °C

2: 87 percent / TFA / CH₂Cl₂ / 12 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.058

Reference yield:

: 600-00-0
ethyl 2-bromoisobutyrate

: 886447-26-3
ethyl 2-[4-[(4R)-benzyloxy-2-pyrrolidinyl]-1-piperazinyl]-2-methylpropionate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / K₂CO₃ / dimethylformamide / 12 h / 20 °C

2: 99 percent / TFA / CH₂Cl₂ / 1 h

3: 87 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl salt; HOBt; Et₃N / dimethylformamide / 12 h / 20 °C

4: 87 percent / TFA / CH₂Cl₂ / 12 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.058