<2R^*(R^*),3(cis)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane

Base Information

• Chemical Name: <2R^*(R^*),3(cis)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane
• CAS No.: 126785-28-2
• Molecular Formula: C₁₈H₂₇NO
• Molecular Weight: 273.418

Synonyms:<2R^*(R^*),3(cis)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane

Chemical Property of <2R^*(R^*),3(cis)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane

Chemical Property:

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Technology Process of <2R^*(R^*),3(cis)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane

There total 12 articles about <2R^*(R^*),3(cis)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-tert-butylcyclohexylidene)-1-phenylethylamine (81583-85-9) → 6-tert-Butyl-2-((R)-1-phenyl-ethyl)-1-oxa-2-aza-spiro[2.5]octane (81583-86-0,116837-78-6,116837-82-2,121251-49-8,126785-26-0,126785-27-1,126785-28-2)

Guidance literature:

With (+)-monoperoxycamphoric acid ((+)-MPCA); In toluene; at -20 ℃; for 0.333333h; Yield given;

DOI:10.1021/ja00168a038

Reference yield:

N-(4-tert-butylcyclohexylidene)-1-phenylethylamine (81583-85-9) → <2S*(R*),3(cis)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane (126785-26-0) + <2S*(R*),3(trans)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane (116837-82-2) + <2R*(R*),3(cis)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane (126785-28-2) + <2R*(R*),3(trans)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane (126785-27-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In toluene; at -20 ℃; for 0.333333h; Yield given. Yields of byproduct given;

DOI:10.1021/ja00168a038

Reference yield:

rac-methylbenzylamine (618-36-0) → <2R*(R*),3(cis)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane (126785-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / Heating

2: m-chloroperoxybenzoic acid (mCPBA) / toluene / 0.33 h / -20 °C

3: toluene / Heating

With 3-chloro-benzenecarboperoxoic acid; In toluene;

DOI:10.1021/ja00168a038

upstream raw materials:

N-(4-tert-butylcyclohexylidene)-1-phenylethylamine

4-tercbutyl-cyclohexanone

rac-methylbenzylamine

<2S^*(R^*),3(cis)>-6-(1,1-dimethylethyl)-2-(1'-phenylethyl)-1-oxa-2-azaspiro<2.5>octane

Downstream raw materials:

(R)-5-tert-Butyl-1-((R)-1-phenyl-ethyl)-azepan-2-one

(S)-5-tert-Butyl-1-((R)-1-phenyl-ethyl)-azepan-2-one

(R)-5-tert-Butyl-1-((S)-1-phenyl-ethyl)-azepan-2-one

(5S,αS)-5-tert-butyl-1-(α-methylbenzyl)hexahydro-2-azepinone

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