ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

Base Information

• Chemical Name: ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate
• CAS No.: 169113-55-7
• Molecular Formula: C₂₃H₂₃Cl₂NO₄
• Molecular Weight: 448.346
• Mol file: 169113-55-7.mol

Synonyms:ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

Chemical Property of ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate

There total 5 articles about ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

ethyl α-methanesulfonyloxy-(3,5-trans)-7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetate → ethyl (Z)-[7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate (169113-54-6) + ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate (169113-55-7)

Guidance literature:

With cesium propionate; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1248/cpb.50.53

Reference yield:

ethyl (2S,3S)-3-carboxylate oxirane-2-carboxylic acid (63734-73-6,66647-16-3,68521-71-1,89886-73-7,93061-20-2,149884-11-7) → ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate (169113-55-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / dichloromethylenedimethyliminium chloride; NaHCO₃ / CH₂Cl₂ / 0 °C

2: 54 percent / K₂CO₃ / ethanol / 20 °C

3: 95 percent / Et₃N / ethyl acetate

4: 18 percent / cesium propionate / dimethylformamide / 80 °C

With cesium propionate; sodium hydrogencarbonate; dichloromethylenedimethyliminium chloride; potassium carbonate; triethylamine; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.50.53

Reference yield:

5-chloro-α-(2-chlorophenyl)-2-(isobutylamino)benzyl alcohol (152906-75-7) → ethyl (E)-[7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,5-dihydro-4,1-benzoxazepin-3(2H)-ylidene]acetate (169113-55-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / dichloromethylenedimethyliminium chloride; NaHCO₃ / CH₂Cl₂ / 0 °C

2: 54 percent / K₂CO₃ / ethanol / 20 °C

3: 95 percent / Et₃N / ethyl acetate

4: 18 percent / cesium propionate / dimethylformamide / 80 °C

With cesium propionate; sodium hydrogencarbonate; dichloromethylenedimethyliminium chloride; potassium carbonate; triethylamine; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.50.53

upstream raw materials:

ethyl (2S,3S)-3-carboxylate oxirane-2-carboxylic acid

5-chloro-α-(2-chlorophenyl)-2-(isobutylamino)benzyl alcohol