benzyl 3-methylbenzofuran-2-yl carbonate

Base Information

• Chemical Name: benzyl 3-methylbenzofuran-2-yl carbonate
• CAS No.: 1531624-02-8
• Molecular Formula: C₁₇H₁₄O₄
• Molecular Weight: 282.296
• Mol file: 1531624-02-8.mol

Synonyms:benzyl 3-methylbenzofuran-2-yl carbonate

Chemical Property of benzyl 3-methylbenzofuran-2-yl carbonate

Chemical Property:

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Technology Process of benzyl 3-methylbenzofuran-2-yl carbonate

There total 1 articles about benzyl 3-methylbenzofuran-2-yl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-methyl-3H-benzofuran-2-one (134940-29-7,32267-71-3) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 3-methylbenzofuran-2-yl carbonate (1531624-02-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 3h; Inert atmosphere;

DOI:10.1039/c3cc47455k

Reference yield: 92.0%

5-methoxy-1-tritylindoline-2,3-dione (1313872-79-5) + benzyl 3-methylbenzofuran-2-yl carbonate (1531624-02-8) → benzyl ((S)-5-methoxy-3-((S)-3-methyl-2-oxo-2,3-dihydrobenzofuran-3-yl)-2-oxo-1-tritylindolin-3-yl)carbonate

Guidance literature:

With C₂₁H₂₁N₄O₃⁽¹⁺⁾*Cl^(1-); N-ethyl-N,N-diisopropylamine; In tert-butyl methyl ether; at 20 ℃; for 24h; stereoselective reaction; Molecular sieve;

DOI:10.1002/anie.202008369

Reference yield: 92.0%

benzyl 3-methylbenzofuran-2-yl carbonate (1531624-02-8) + 1-trityl-1H-indole-2,3-dione (41128-14-7) → benzyl ((S)-3-((S)-3-methyl-2-oxo-2,3-dihydrobenzofuran-3-yl)-2-oxo-1-tritylindolin-3-yl)carbonate

Guidance literature:

With C₂₁H₂₁N₄O₃⁽¹⁺⁾*Cl^(1-); N-ethyl-N,N-diisopropylamine; In tert-butyl methyl ether; at 20 ℃; for 24h; stereoselective reaction; Catalytic behavior; Molecular sieve;

DOI:10.1002/anie.202008369

upstream raw materials:

3-methyl-3H-benzofuran-2-one

benzyl chloroformate

Downstream raw materials:

(R)-benzyl 3-methyl-2-oxo-2,3-dihydrobenzofuran-3-carboxylate