(R)-S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2-methylpropanethioate

Base Information

Chemical Name:(R)-S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2-methylpropanethioate
CAS No.:1333123-36-6
Molecular Formula:C₃₃H₄₂ClN₃O₆S
Molecular Weight:644.232
Hs Code.:

(R)-S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2-methylpropanethioate

Synonyms:(R)-S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2-methylpropanethioate

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Chemical Property of (R)-S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2-methylpropanethioate

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Technology Process of (R)-S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2-methylpropanethioate

There total 2 articles about (R)-S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2-methylpropanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 869195-52-8
(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienoic acid

: 1333123-45-7
S-(R)-2-acetamidoethyl 3-((R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2-methylpropanethioate

: 1333123-36-6
(R)-S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2-methylpropanethioate

Guidance literature:: S-(R)-2-acetamidoethyl 3-((R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2-methylpropanethioate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienoic acid; With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/ja204716f

Reference yield:

: 1333123-42-4
(R)-2-acetamidoethyl 3-(tert-butoxycarbonylamino)-2-methylpropanethioate

: 1333123-36-6
(R)-S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2-methylpropanethioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

1.2: 18 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.2: 18 h / 20 °C

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja204716f

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 1333123-36-6
(R)-S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2-methylpropanethioate

: C₃₅H₄₅ClN₂O₈

Guidance literature:: With 1,4-dihydronicotinamide adenine dinucleotide; tris(2-carboxyethyl)phosphine; N-terminal-His-tagged CrpD-M₂ peptide synthetase; recombinant Crp TE enzyme; tris hydrochloride; ATP; NADPH; magnesium chloride; In water; pH=7.5; Enzymatic reaction;
DOI:10.1021/ja204716f