N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-cyclopropylacetamide

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Chemical Name:N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-cyclopropylacetamide
CAS No.:916051-41-7
Molecular Formula:C₂₄H₁₉ClN₄O₂S
Molecular Weight:462.959
Hs Code.:

Synonyms:N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-cyclopropylacetamide

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Chemical Property of N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-cyclopropylacetamide

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Technology Process of N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-cyclopropylacetamide

There total 7 articles about N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-cyclopropylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 4113-04-6
quinoline-6-carbaldehyde

: 916050-65-2
2-[(5-amino-2-chlorophenyl)amino]-1,3-thiazol-4(5H)-one

: 916051-41-7
N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-cyclopropylacetamide

Guidance literature:: 2-[(5-amino-2-chlorophenyl)amino]-1,3-thiazol-4(5H)-one; cyclopropylacetyl chloride; In 1,4-dioxane; for 2h;

quinoline-6-carbaldehyde; With sodium acetate; In ethanol; at 180 ℃; for 0.666667h; Microwave heating;

Reference yield:

: 701294-30-6
2-[(2-chloro-5-nitrophenyl)amino]-1,3-thiazol-4(5H)-one

: 916051-41-7
N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-cyclopropylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 760.05 Torr

2.1: 1,4-dioxane / 2 h

2.2: 0.67 h / 180 °C / Microwave heating

With hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol;

Reference yield:

: 341036-39-3
2-chloro-5-nitrophenylthiourea

: 916051-41-7
N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-cyclopropylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4 h / 130 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 760.05 Torr

3.1: 1,4-dioxane / 2 h

3.2: 0.67 h / 180 °C / Microwave heating

With hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol;