ethyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate

Base Information

• Chemical Name: ethyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate
• CAS No.: 1092071-08-3
• Molecular Formula: C₃₃H₃₄ClF₂N₃O₅
• Molecular Weight: 626.1
• Mol file: 1092071-08-3.mol

Synonyms:ethyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate

Chemical Property of ethyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate

There total 1 articles about ethyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 4-bromobutyrate (2969-81-5) + C27H24ClF2N3O3 (1092071-04-9) → ethyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (1092071-08-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

DOI:10.1021/jm8006454

Reference yield:

ethyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (1092071-08-3) → (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric acid (1092170-40-5)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm8006454

upstream raw materials:

Ethyl 4-bromobutyrate

C₂₇H₂₄ClF₂N₃O₃

Downstream raw materials:

(R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric acid