N-Benzyl-N'-<<1R-(1α,2β,3α,4β,5β)>-2-(benzyloxy)-1-<(benzyloxy)methyl>-1-hydroxy-3,4-bis(methoxymethoxy)-1-cyclopent-5-yl>thiourea

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Chemical Name:N-Benzyl-N'-<<1R-(1α,2β,3α,4β,5β)>-2-(benzyloxy)-1-<(benzyloxy)methyl>-1-hydroxy-3,4-bis(methoxymethoxy)-1-cyclopent-5-yl>thiourea
CAS No.:144811-30-3
Molecular Formula:C₃₂H₄₀N₂O₇S
Molecular Weight:596.745
Hs Code.:

Synonyms:N-Benzyl-N'-<<1R-(1α,2β,3α,4β,5β)>-2-(benzyloxy)-1-<(benzyloxy)methyl>-1-hydroxy-3,4-bis(methoxymethoxy)-1-cyclopent-5-yl>thiourea

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Chemical Property of N-Benzyl-N'-<<1R-(1α,2β,3α,4β,5β)>-2-(benzyloxy)-1-<(benzyloxy)methyl>-1-hydroxy-3,4-bis(methoxymethoxy)-1-cyclopent-5-yl>thiourea

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Technology Process of N-Benzyl-N'-<<1R-(1α,2β,3α,4β,5β)>-2-(benzyloxy)-1-<(benzyloxy)methyl>-1-hydroxy-3,4-bis(methoxymethoxy)-1-cyclopent-5-yl>thiourea

There total 2 articles about N-Benzyl-N'-<<1R-(1α,2β,3α,4β,5β)>-2-(benzyloxy)-1-<(benzyloxy)methyl>-1-hydroxy-3,4-bis(methoxymethoxy)-1-cyclopent-5-yl>thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 622-78-6
Benzyl isothiocyanate

: 144811-34-7
(1R,2R,3S,4R,5S)-2-Amino-5-benzyloxy-1-benzyloxymethyl-3,4-bis-methoxymethoxy-cyclopentanol

: 144811-30-3
N-Benzyl-N'-<<1R-(1α,2β,3α,4β,5β)>-2-(benzyloxy)-1-<(benzyloxy)methyl>-1-hydroxy-3,4-bis(methoxymethoxy)-1-cyclopent-5-yl>thiourea

Guidance literature:: In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1021/jo00083a023

Reference yield:

: 144811-29-0
<1R-(1α,2β,3α,4β,5β)>-5-Azido-2-(benzyloxy)-1-<(benzyloxy)methyl>-3,4-bis(methoxymethoxy)-1-cyclopentanol

: 144811-30-3
N-Benzyl-N'-<<1R-(1α,2β,3α,4β,5β)>-2-(benzyloxy)-1-<(benzyloxy)methyl>-1-hydroxy-3,4-bis(methoxymethoxy)-1-cyclopent-5-yl>thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / LiAlH₄ / diethyl ether / 4 h / 0 °C

2: 97 percent / tetrahydrofuran / 3 h / Ambient temperature

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00083a023

Reference yield:

: 144811-30-3
N-Benzyl-N'-<<1R-(1α,2β,3α,4β,5β)>-2-(benzyloxy)-1-<(benzyloxy)methyl>-1-hydroxy-3,4-bis(methoxymethoxy)-1-cyclopent-5-yl>thiourea

: 144811-32-5
<3aR-(3aα,4α,5β,6α,6aα)>-2-(Benzylamino)-5-(benzyloxy)-4-<(benzyloxy)methyl>-3a,5,6,6a-tetrahydro-4H-cyclopentoxazole-4,6-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / 0.5 M aq. HCl / dioxane / 24 h / 60 °C

2: 2-chloro-3-ethylbenzoxazolium tetrafluoroborate / acetonitrile / 1 h / 0 °C

3: Et₃N / acetonitrile / 3 h / 0 °C

With hydrogenchloride; 3-ethyl-2-chlorobenzoxazolium tetrafluoroborate; triethylamine; In 1,4-dioxane; acetonitrile;
DOI:10.1021/jo00083a023