Butyl-carbamic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

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Chemical Name:Butyl-carbamic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
CAS No.:130884-77-4
Molecular Formula:C₂₅H₃₂FN₃O₄S
Molecular Weight:489.611
Hs Code.:

Synonyms:Butyl-carbamic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

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Chemical Property of Butyl-carbamic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

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Technology Process of Butyl-carbamic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

There total 3 articles about Butyl-carbamic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348-40-3
2-amino-6-fluoro-1,3-benzothiazole

: 130884-77-4
Butyl-carbamic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 75.5 percent / aq. NaOH / Heating

2: 15.4 percent / 16 h / 160 °C

3: aq. K₂CO₃ / acetone / 17 h / Heating

4: Et₃N / benzene / 44 h / Heating

With sodium hydroxide; potassium carbonate; triethylamine; In acetone; benzene;
DOI:10.1021/jm00106a032

Reference yield:

: 100492-87-3
(2S,3S)-8-Fluoro-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

: 130884-77-4
Butyl-carbamic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. K₂CO₃ / acetone / 17 h / Heating

2: Et₃N / benzene / 44 h / Heating

With potassium carbonate; triethylamine; In acetone; benzene;
DOI:10.1021/jm00106a032