Technology Process of (3aS,6aR)-(3,3-dimethoxyhexahydropyrrolo[3,2-b]pyrrol-1-yl)phenylmethanone
There total 15 articles about (3aS,6aR)-(3,3-dimethoxyhexahydropyrrolo[3,2-b]pyrrol-1-yl)phenylmethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
at 20 ℃;
for 1.41667h;
DOI:10.1016/j.bmc.2004.10.060
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 3.42 g / triethylamine / CH2Cl2 / 1 h / 0 °C
2.1: sodium azide / dimethylformamide / 1.5 h / 60 °C
3.1: triphenylphosphine / tetrahydrofuran / 7.5 h / 45 °C
4.1: sodium carbonate / dioxane; H2O / 1 h
5.1: meta-chloroperbenzoic acid / CH2Cl2 / 16 h / 20 °C
6.1: hydrogen / Pd/C / ethanol / 0 - 20 °C
6.2: 61 percent / sodium carbonate / dioxane; H2O / 1 h
7.1: HCl / dioxane / 1.08 h / 20 °C
8.1: N-methylmorpholine / dimethylformamide / 1.75 h / 20 °C
9.1: 78 percent / Dess-Martin periodinane / CH2Cl2 / 16 h
10.1: 77 percent / para-toluenesulfonic acid / methanol / 16 h / 65 °C
11.1: hydrogen / Pd/C / methanol / 1.42 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; sodium azide; hydrogen; sodium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
4.1: Schotten-Baumann reaction / 6.2: Schotten-Baumann reaction;
DOI:10.1016/j.bmc.2004.10.060
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium carbonate / dioxane; H2O / 1 h
2.1: meta-chloroperbenzoic acid / CH2Cl2 / 16 h / 20 °C
3.1: hydrogen / Pd/C / ethanol / 0 - 20 °C
3.2: 61 percent / sodium carbonate / dioxane; H2O / 1 h
4.1: HCl / dioxane / 1.08 h / 20 °C
5.1: N-methylmorpholine / dimethylformamide / 1.75 h / 20 °C
6.1: 78 percent / Dess-Martin periodinane / CH2Cl2 / 16 h
7.1: 77 percent / para-toluenesulfonic acid / methanol / 16 h / 65 °C
8.1: hydrogen / Pd/C / methanol / 1.42 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; hydrogen; sodium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
1.1: Schotten-Baumann reaction / 3.2: Schotten-Baumann reaction;
DOI:10.1016/j.bmc.2004.10.060
![(3aR,6aS)-4-benzoyl-6,6-dimethoxyhexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester](/Databaselist/images/loading.webp)
