(E)-ethyl 4-(3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)acryloyl)benzoate

Base Information

Chemical Name:(E)-ethyl 4-(3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)acryloyl)benzoate
CAS No.:1365620-63-8
Molecular Formula:C₁₉H₁₇BO₅
Molecular Weight:336.152
Hs Code.:

Synonyms:(E)-ethyl 4-(3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)acryloyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-ethyl 4-(3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)acryloyl)benzoate

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Technology Process of (E)-ethyl 4-(3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)acryloyl)benzoate

There total 6 articles about (E)-ethyl 4-(3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)acryloyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.4%

: 1195621-94-3
1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbaldehyde

: 38430-55-6
ethyl-4-acetylbenzoate

: 1365620-63-8
(E)-ethyl 4-(3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)acryloyl)benzoate

Guidance literature:: With acetyl chloride; In ethanol; at 0 - 20 ℃; for 36h; Inert atmosphere;
DOI:10.1021/jm2012408

Reference yield:

: 947162-87-0
1,3-dihydro-1-hydroxy-6-hydroxymethyl-2,1-benzoxaborole

: 1365620-63-8
(E)-ethyl 4-(3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)acryloyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 20 °C

2: acetyl chloride / ethanol / 36 h / 0 - 20 °C / Inert atmosphere

With acetyl chloride; pyridinium chlorochromate; In ethanol; dichloromethane; 2: Aldol condensation;
DOI:10.1021/jm2012408

Reference yield:

: C₂₄H₃₉BO₆

: 1365620-63-8
(E)-ethyl 4-(3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)acryloyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 6 h / 20 °C

2: pyridinium chlorochromate / dichloromethane / 20 °C

3: acetyl chloride / ethanol / 36 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; acetyl chloride; pyridinium chlorochromate; In ethanol; dichloromethane; water; 3: Aldol condensation;
DOI:10.1021/jm2012408