N-(pentafluorophenyloxycarbonyl)methyl-(2'R,4'R)-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine

Base Information

Chemical Name:N-(pentafluorophenyloxycarbonyl)methyl-(2'R,4'R)-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine
CAS No.:320727-46-6
Molecular Formula:C₂₆H₁₉F₅N₄O₆
Molecular Weight:578.452
Hs Code.:

Synonyms:N-(pentafluorophenyloxycarbonyl)methyl-(2'R,4'R)-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine

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Chemical Property of N-(pentafluorophenyloxycarbonyl)methyl-(2'R,4'R)-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine

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Technology Process of N-(pentafluorophenyloxycarbonyl)methyl-(2'R,4'R)-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine

There total 8 articles about N-(pentafluorophenyloxycarbonyl)methyl-(2'R,4'R)-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 14533-84-7
pentafluorophenyl trifloroacetate

: N-carboxymethyl-(2'R,4'R)-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine trifluoroacetic acid salt

: 320727-46-6
N-(pentafluorophenyloxycarbonyl)methyl-(2'R,4'R)-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1039/b306156f

Reference yield:

: 320727-45-5
(2'R,4'R)-N-[(tert-butoxycarbonyl)methyl]-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine

: 320727-46-6
N-(pentafluorophenyloxycarbonyl)methyl-(2'R,4'R)-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / 3 h / 20 °C

2: 78 percent / pyridine / dimethylformamide / 2 h / 20 °C

With pyridine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b306156f

Reference yield:

: 136918-14-4,85-41-6
phthalimide

: 320727-46-6
N-(pentafluorophenyloxycarbonyl)methyl-(2'R,4'R)-2'-[(phthalimido)methyl]-4'-(thymin-1-yl)pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / PPh₃; DEAD / tetrahydrofuran / 15 h / -15 - 20 °C

2: 86 percent / CF₃COOH / CH₂Cl₂ / 4 h

3: 92 percent / DIPEA / dimethylformamide / 18 h / 0 - 20 °C

4: CF₃COOH / CH₂Cl₂ / 3 h

5: pyridine / dimethylformamide / 2 h

With pyridine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1039/b006903p