5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoic acid (1R,4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl ester

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Chemical Name:5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoic acid (1R,4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl ester
CAS No.:119594-12-6
Molecular Formula:C₄₈H₇₀O₆Si₂
Molecular Weight:799.251
Hs Code.:

5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoic acid (1R,4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl ester

Synonyms:5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoic acid (1R,4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl ester

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Chemical Property of 5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoic acid (1R,4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl ester

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Technology Process of 5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoic acid (1R,4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl ester

There total 8 articles about 5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoic acid (1R,4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119594-21-7
5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoyl chloride

: 119594-11-5
(1R,4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enol

: 119594-12-6
5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoic acid (1R,4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ja00189a069

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 119594-12-6
5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoic acid (1R,4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: PPTS / CH₂Cl₂ / Ambient temperature

2: Saegusa oxidation

3: NaBH₄, CeCl₃ / methanol / -30 °C

4: KN(TMS)2 / tetrahydrofuran / -78 °C

With sodium tetrahydroborate; cerium(III) chloride; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00189a069

Reference yield:

: 5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanal

: 119594-12-6
5-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-pentanoic acid (1R,4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: RuO₂, NaIO₄ / CCl₄; acetonitrile; H₂O / Ambient temperature

2: (COCl)2 / dimethylformamide; CH₂Cl₂ / Ambient temperature

3: KN(TMS)2 / tetrahydrofuran / -78 °C

With ruthenium(IV) oxide; sodium periodate; oxalyl dichloride; potassium hexamethylsilazane; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00189a069