(1-{benzyl-[3-cyano-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (1-{benzyl-[3-cyano-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester
• CAS No.: 215534-65-9
• Molecular Formula: C₃₇H₃₈N₃O₄P
• Molecular Weight: 619.7

Synonyms:(1-{benzyl-[3-cyano-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Chemical Property of (1-{benzyl-[3-cyano-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (1-{benzyl-[3-cyano-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

There total 4 articles about (1-{benzyl-[3-cyano-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-N-Boc-Ala (15761-38-3) → (1-{benzyl-[3-cyano-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester (215534-65-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / EDCI; HOBt

2: 100 percent / LiOH / H₂O; tetrahydrofuran

3: EDCI; DMAP / CH₂Cl₂

With dmap; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; 1: Acylation / 2: Hydrolysis / 3: Condensation;

DOI:10.1021/ol990355r

Reference yield:

ethyl 2-(benzylamino)acetate (6436-90-4) → (1-{benzyl-[3-cyano-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester (215534-65-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / EDCI; HOBt

2: 100 percent / LiOH / H₂O; tetrahydrofuran

3: EDCI; DMAP / CH₂Cl₂

With dmap; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; 1: Acylation / 2: Hydrolysis / 3: Condensation;

DOI:10.1021/ol990355r

Reference yield:

Nα-Boc-Ala-Nα-benzylglycine ethyl ester (86666-85-5) → (1-{benzyl-[3-cyano-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester (215534-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / LiOH / H₂O; tetrahydrofuran

2: EDCI; DMAP / CH₂Cl₂

With dmap; lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; 1: Hydrolysis / 2: Condensation;

DOI:10.1021/ol990355r

upstream raw materials:

cyanomethylene triphenylphosphorane

N-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-N-(phenylmethyl)glycine

L-N-Boc-Ala

ethyl 2-(benzylamino)acetate

Downstream raw materials:

(benzyl-{3-[benzyl-(2-tert-butoxycarbonylamino-propionyl)-amino]-2-oxo-propionyl}-amino)-acetic acid ethyl ester

2,8-dibenzyl-6-methyl-2,3-dihydro-8H-pyrazino[1,2-a]pyrazine-1,4,7-trione

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