Ethyl N-[(6-hydroxy-2-{4-[(1-methylethyl)oxy]phenyl}-5-quinoxalinyl)carbonyl]glycinate

Base Information

Chemical Name:Ethyl N-[(6-hydroxy-2-{4-[(1-methylethyl)oxy]phenyl}-5-quinoxalinyl)carbonyl]glycinate
CAS No.:1160684-59-2
Molecular Formula:C₂₂H₂₃N₃O₅
Molecular Weight:409.442
Hs Code.:

Synonyms:Ethyl N-[(6-hydroxy-2-{4-[(1-methylethyl)oxy]phenyl}-5-quinoxalinyl)carbonyl]glycinate

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Chemical Property of Ethyl N-[(6-hydroxy-2-{4-[(1-methylethyl)oxy]phenyl}-5-quinoxalinyl)carbonyl]glycinate

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Technology Process of Ethyl N-[(6-hydroxy-2-{4-[(1-methylethyl)oxy]phenyl}-5-quinoxalinyl)carbonyl]glycinate

There total 9 articles about Ethyl N-[(6-hydroxy-2-{4-[(1-methylethyl)oxy]phenyl}-5-quinoxalinyl)carbonyl]glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.8%

: 1160682-32-5
ethyl N-[(2-bromo-6-hydroxy-5-quinoxalinyl)carbonyl]glycinate

: 153624-46-5
4-(isopropoxy)phenylboronic acid

: 1160684-59-2
Ethyl N-[(6-hydroxy-2-{4-[(1-methylethyl)oxy]phenyl}-5-quinoxalinyl)carbonyl]glycinate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160684-59-2
Ethyl N-[(6-hydroxy-2-{4-[(1-methylethyl)oxy]phenyl}-5-quinoxalinyl)carbonyl]glycinate

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid; nitric acid / 0 - 20 °C

2: ammonium hydroxide / ethanol; water / 20 °C

3: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2585.81 Torr

5: toluene; acetonitrile / 0.25 h / 20 °C

6: trichlorophosphate / Reflux

7: boron tribromide / dichloromethane / 20 °C

8: triethylamine; HATU / N,N-dimethyl-formamide

9: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With ammonium hydroxide; sulfuric acid; hydrogen; nitric acid; boron tribromide; sodium hydride; potassium carbonate; triethylamine; HATU; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1160682-17-6
methyl 2,3-diamino-6-methoxybenzoate

: 1160684-59-2
Ethyl N-[(6-hydroxy-2-{4-[(1-methylethyl)oxy]phenyl}-5-quinoxalinyl)carbonyl]glycinate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene; acetonitrile / 0.25 h / 20 °C

2: trichlorophosphate / Reflux

3: boron tribromide / dichloromethane / 20 °C

4: triethylamine; HATU / N,N-dimethyl-formamide

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With boron tribromide; potassium carbonate; triethylamine; HATU; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;