C₄₇H₅₀ClF₂N₇O₅

Base Information

Chemical Name:C₄₇H₅₀ClF₂N₇O₅
CAS No.:1369595-88-9
Molecular Formula:C₄₇H₅₀ClF₂N₇O₅
Molecular Weight:866.408
Hs Code.:

C<sub>47</sub>H<sub>50</sub>ClF<sub>2</sub>N<sub>7</sub>O<sub>5</sub>

Synonyms:C₄₇H₅₀ClF₂N₇O₅

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₄₇H₅₀ClF₂N₇O₅

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Technology Process of C₄₇H₅₀ClF₂N₇O₅

There total 11 articles about C₄₇H₅₀ClF₂N₇O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1369594-33-1
tert-butyl (2S,4R)-2-(5-bromo-1H-imidazol-2-yl)-4-fluoropyrrolidine-1-carboxylate

: 1369595-87-8
C₃₅H₄₀B₂ClNO₅

: 1369595-88-9
C₄₇H₅₀ClF₂N₇O₅

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 90 ℃; for 16h;

Reference yield:

: 30186-18-6
4'-bromo-2'-hydroxyacetophenone

: 1369595-88-9
C₄₇H₅₀ClF₂N₇O₅

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / ethanol / 6 h / Reflux

2: polyphosphoric acid / 2 h / 80 °C

3: N-chloro-succinimide / tetrahydrofuran; dichloromethane / 2.67 h / 0 - 20 °C

4: p-toluenesulfonyl chloride / toluene / 12 h / 170 °C / Microwave irradiation

5: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

6: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

With N-chloro-succinimide; potassium acetate; potassium carbonate; acetic acid; p-toluenesulfonyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene;

Reference yield:

: 203866-14-2
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid

: 1369595-88-9
C₄₇H₅₀ClF₂N₇O₅

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 15 h / 0 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

2.2: 1.5 h / -78 - 0 °C

3.1: ammonia / methanol / 39 h / 20 °C

4.1: N-Bromosuccinimide / acetonitrile / 15 h / 20 °C

5.1: sodium sulfite / ethanol; water / 39 h / Reflux

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

With N-Bromosuccinimide; borane-THF; oxalyl dichloride; ammonia; potassium carbonate; dimethyl sulfoxide; sodium sulfite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;