(2-Ethynyl-5-fluorophenyl)methanol

Base Information

Chemical Name:(2-Ethynyl-5-fluorophenyl)methanol
CAS No.:229028-01-7
Molecular Formula:C9H7 F O
Molecular Weight:150.152
Hs Code.:
DSSTox Substance ID:DTXSID90572968
Nikkaji Number:J1.252.938D
Wikidata:Q82461514
Mol file:229028-01-7.mol

Synonyms:(2-ethynyl-5-fluorophenyl)methanol;229028-01-7;Benzenemethanol, 2-ethynyl-5-fluoro- (9CI);DTXSID90572968

Suppliers and Price of (2-Ethynyl-5-fluorophenyl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (2-Ethynyl-5-fluorophenyl)methanol

Chemical Property:

PSA：20.23000
LogP:1.29930
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:150.048093005
Heavy Atom Count:11
Complexity:170

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C#CC1=C(C=C(C=C1)F)CO

Technology Process of (2-Ethynyl-5-fluorophenyl)methanol

There total 8 articles about (2-Ethynyl-5-fluorophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 229027-94-5
{5-Fluoro-2-[2-(triisopropylsilyl)ethyn-1-yl]phenyl}methanol

: 229028-01-7
(2-Ethynyl-5-fluorophenyl)methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.25h;
DOI:10.1135/cccc19990649

Reference yield:

: 202865-66-5
2-bromo-5-fluorobenzyl alcohol

: 229028-01-7
(2-Ethynyl-5-fluorophenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / piperidine / Pd(PPh₃)4 / 20 h / 80 °C

2: 99 percent / TBAF / tetrahydrofuran / 0.25 h / 20 °C

With piperidine; tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1: Arylation / 2: Substitution;
DOI:10.1135/cccc19990649

Reference yield:

: 5-fluoro-(2-(trimethylsilyl)ethynyl)benzaldehyde

: 229028-01-7
(2-Ethynyl-5-fluorophenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 0 °C

2: potassium carbonate / methanol / 1 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1021/ol303188u