(R)-((S)-3-Benzylcarbamoyl-3-methyl-2-methylene-6-oxo-piperidin-1-yl)-phenyl-acetic acid ethyl ester

Base Information

Chemical Name:(R)-((S)-3-Benzylcarbamoyl-3-methyl-2-methylene-6-oxo-piperidin-1-yl)-phenyl-acetic acid ethyl ester
CAS No.:203314-71-0
Molecular Formula:C₂₅H₂₈N₂O₄
Molecular Weight:420.508
Hs Code.:

Synonyms:(R)-((S)-3-Benzylcarbamoyl-3-methyl-2-methylene-6-oxo-piperidin-1-yl)-phenyl-acetic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-((S)-3-Benzylcarbamoyl-3-methyl-2-methylene-6-oxo-piperidin-1-yl)-phenyl-acetic acid ethyl ester

Chemical Property:

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Technology Process of (R)-((S)-3-Benzylcarbamoyl-3-methyl-2-methylene-6-oxo-piperidin-1-yl)-phenyl-acetic acid ethyl ester

There total 2 articles about (R)-((S)-3-Benzylcarbamoyl-3-methyl-2-methylene-6-oxo-piperidin-1-yl)-phenyl-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 882-36-0
N-benzyl-3-oxobutanamide

: 203314-71-0
(R)-((S)-3-Benzylcarbamoyl-3-methyl-2-methylene-6-oxo-piperidin-1-yl)-phenyl-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: EtONa / ethanol

2: 1.) BF₃/Et₂O, NaHCO₃ / 1.) THF, reflux, 2.) THF, RT

With diethyl ether; boron trifluoride; sodium ethanolate; sodium hydrogencarbonate; In ethanol;
DOI:10.1021/ja9729591

Reference yield:

: 90033-07-1
N-benzyl-2-methyl-3-oxobutanamide

: 17609-48-2
(R)-2-phenylglycine ethyl ester hydrochloride

: 42561-03-5
C₆H₈O₄

: 203314-71-0
(R)-((S)-3-Benzylcarbamoyl-3-methyl-2-methylene-6-oxo-piperidin-1-yl)-phenyl-acetic acid ethyl ester

Guidance literature:: With diethyl ether; boron trifluoride; sodium hydrogencarbonate; Yield given. Multistep reaction; 1.) THF, reflux, 2.) THF, RT;
DOI:10.1021/ja9729591

Reference yield:

: 203314-71-0
(R)-((S)-3-Benzylcarbamoyl-3-methyl-2-methylene-6-oxo-piperidin-1-yl)-phenyl-acetic acid ethyl ester

: (R)-((R)-4-Benzylcarbamoyl-4-methyl-5-oxo-hexanoylamino)-phenyl-acetic acid ethyl ester

: (R)-((S)-4-Benzylcarbamoyl-4-methyl-5-oxo-hexanoylamino)-phenyl-acetic acid ethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/ja9729591