Chemical Property of Arachidonylcyclopropylamide
Chemical Property:
- PSA：29.10000
- LogP:6.80160
- Storage Temp.:−20°C
- Sensitive.:Air Sensitive
- Solubility.:DMSO: soluble
- XLogP3:6.6
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:15
- Exact Mass:343.287514804
- Heavy Atom Count:25
- Complexity:441
- Purity/Quality:
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99% *data from raw suppliers
Arachidonylcyclopropylamide *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCCCC=CCC=CCC=CCC=CCCCC(=O)NC1CC1
- Isomeric SMILES:CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NC1CC1
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Description
Arachidonoyl cyclopropylamide (ACPA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 2.2 and 715 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACPA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.
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Uses
A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACPA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2
(CB2R).
