2,2,2-trifluoro-1-(1H-indol-2-yl)ethanone

Base Information

Chemical Name:2,2,2-trifluoro-1-(1H-indol-2-yl)ethanone
CAS No.:228873-77-6
Molecular Formula:C₁₀H₆F₃NO
Molecular Weight:213.159
Hs Code.:
DSSTox Substance ID:DTXSID20399185
Nikkaji Number:J1.100.817H
Wikidata:Q82201579
Mol file:228873-77-6.mol

Synonyms:2,2,2-trifluoro-1-(1H-indol-2-yl)ethanone;228873-77-6;trifluoroacetylindole;SCHEMBL5377871;2-(Trifluoroacetyl)-1H-indole;DTXSID20399185;VSPZYLFNHKDKQI-UHFFFAOYSA-N;EN300-1932377;2,2,2-trifluoro-1-(1H-indol-2-yl)ethan-1-one

Suppliers and Price of 2,2,2-trifluoro-1-(1H-indol-2-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2,2,2-TRIFLUORO-1-(1H-INDOL-2-YL)-ETHANONE 95.00%
5MG
$ 495.12

AccelPharmtech
2,2,2-trifluoro-1-(1H-indol-2-yl)-Ethanone 97.00%
25G
$ 4010.00

AccelPharmtech
2,2,2-trifluoro-1-(1H-indol-2-yl)-Ethanone 97.00%
5G
$ 2180.00

Total 2 raw suppliers

Chemical Property of 2,2,2-trifluoro-1-(1H-indol-2-yl)ethanone

Chemical Property:

PSA：32.86000
LogP:2.91290
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:213.04014830
Heavy Atom Count:15
Complexity:264

Purity/Quality:

99%+ ^*data from raw suppliers

2,2,2-TRIFLUORO-1-(1H-INDOL-2-YL)-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=C(N2)C(=O)C(F)(F)F

Technology Process of 2,2,2-trifluoro-1-(1H-indol-2-yl)ethanone

There total 6 articles about 2,2,2-trifluoro-1-(1H-indol-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1402148-99-5
tert-butyl 2-(2,2,2-trifluoroacetyl)-1H-indole-1-carboxylate

: 228873-77-6
2,2,2-trifluoro-1-(1H-indol-2-yl)ethan-1-one

Guidance literature:: In 2,2,2-trifluoroethanol; at 150 ℃; for 0.25h; Microwave irradiation;
DOI:10.1002/ejoc.201402354

Reference yield: 68.0%

: 1334583-78-6
2,2,2-trifluoro-1-(4,5,6,7-tetrahydro-1H-indol-2-yl)ethanol

: 228873-77-6
2,2,2-trifluoro-1-(1H-indol-2-yl)ethan-1-one

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; for 10h; Reflux;
DOI:10.1016/j.tetlet.2011.07.071

Reference yield: 61.0%

: 120-72-9
indole

: 76-05-1
trifluoroacetic acid

: 228873-77-6
2,2,2-trifluoro-1-(1H-indol-2-yl)ethan-1-one

Guidance literature:: indole; With potassium tert-butylate; tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.416667h;

With copper(I) bromide dimethylsulfide complex; at -78 ℃; for 0.666667h;

trifluoroacetic acid; at -78 ℃; for 1.5h;
DOI:10.3987/COM-99-8480