2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2R,3S)-(9CI)

Base Information

• Chemical Name: 2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2R,3S)-(9CI)
• CAS No.: 228868-33-5
• Molecular Formula: C₆H₉NO₃
• Molecular Weight: 143.142
• Mol file: 228868-33-5.mol

Synonyms:2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2R,3S)-(9CI)

Chemical Property of 2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2R,3S)-(9CI)

Chemical Property:

• PSA: 55.40000
• LogP: -0.37730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2R,3S)-(9CI)

There total 2 articles about 2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2R,3S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-methyl-4-oxo-azetidine-2-carboxylic acid methyl ester (228868-32-4) → (2R,3S)-3-Methyl-4-oxo-azetidine-2-carboxylic acid methyl ester (228868-33-5)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1016/S0960-894X(98)00504-6

Reference yield:

(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-methyl-4-oxo-azetidine-2-carboxylic acid (127062-71-9) → (2R,3S)-3-Methyl-4-oxo-azetidine-2-carboxylic acid methyl ester (228868-33-5)

Guidance literature:

Multi-step reaction with 2 steps

2: aq. HCl / methanol

With hydrogenchloride; In methanol;

DOI:10.1016/S0960-894X(98)00504-6

Reference yield:

(2R,3S)-3-Methyl-4-oxo-azetidine-2-carboxylic acid methyl ester (228868-33-5) → (2R,3R)-3-Methyl-2-(toluene-4-sulfonyloxymethyl)-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: LiAlH₄ / 0 - 20 °C

3: NEt₃ / CH₂Cl₂

With lithium aluminium tetrahydride; triethylamine; In dichloromethane;

DOI:10.1016/S0960-894X(98)00504-6

upstream raw materials:

(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-methyl-4-oxo-azetidine-2-carboxylic acid methyl ester

(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-methyl-4-oxo-azetidine-2-carboxylic acid