2-Ethoxy-5-formyl-6-(2-methyl-2,3-dihydro-indol-1-yl)-4-phenyl-nicotinonitrile

Base Information

Chemical Name:2-Ethoxy-5-formyl-6-(2-methyl-2,3-dihydro-indol-1-yl)-4-phenyl-nicotinonitrile
CAS No.:147034-24-0
Molecular Formula:C₂₄H₂₁N₃O₂
Molecular Weight:383.45
Hs Code.:

Synonyms:2-Ethoxy-5-formyl-6-(2-methyl-2,3-dihydro-indol-1-yl)-4-phenyl-nicotinonitrile

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Chemical Property of 2-Ethoxy-5-formyl-6-(2-methyl-2,3-dihydro-indol-1-yl)-4-phenyl-nicotinonitrile

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Technology Process of 2-Ethoxy-5-formyl-6-(2-methyl-2,3-dihydro-indol-1-yl)-4-phenyl-nicotinonitrile

There total 1 articles about 2-Ethoxy-5-formyl-6-(2-methyl-2,3-dihydro-indol-1-yl)-4-phenyl-nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 143815-60-5
2-chloro-5-cyano-6-ethoxy-4-phenylpyridine-3-carboxaldehyde

: 6872-06-6
2-methyl indoline

: 147034-24-0
2-Ethoxy-5-formyl-6-(2-methyl-2,3-dihydro-indol-1-yl)-4-phenyl-nicotinonitrile

Guidance literature:: With triethylamine; In tetrahydrofuran; for 0.166667h; Heating;
DOI:10.1055/s-1993-25821

Reference yield: 91.0%

: 147034-24-0
2-Ethoxy-5-formyl-6-(2-methyl-2,3-dihydro-indol-1-yl)-4-phenyl-nicotinonitrile

: 109-77-3
malononitrile

: 147034-19-3
2-[5-Cyano-6-ethoxy-2-(2-methyl-2,3-dihydro-indol-1-yl)-4-phenyl-pyridin-3-ylmethylene]-malononitrile

Guidance literature:: With ammonium acetate; N-butylamine; In dichloromethane; for 2h; Heating;
DOI:10.1055/s-1993-25821

Reference yield:

: 147034-24-0
2-Ethoxy-5-formyl-6-(2-methyl-2,3-dihydro-indol-1-yl)-4-phenyl-nicotinonitrile

: 2-(8-Cyano-9-ethoxy-1-methyl-7-phenyl-1,2-dihydro-6H-10,10b-diaza-aceanthrylen-6-yl)-malononitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / BuNH₂, NH₄OAc / CH₂Cl₂ / 2 h / Heating

2: 63 percent / methanol / 2 h / Heating

With ammonium acetate; N-butylamine; In methanol; dichloromethane;
DOI:10.1055/s-1993-25821