[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrole-1-yl]methyl(diphenyl)phosphine oxide

Base Information

Chemical Name:[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrole-1-yl]methyl(diphenyl)phosphine oxide
CAS No.:1342886-70-7
Molecular Formula:C₃₉H₃₄FN₂O₂P
Molecular Weight:612.683
Hs Code.:

Synonyms:[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrole-1-yl]methyl(diphenyl)phosphine oxide

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Chemical Property of [3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrole-1-yl]methyl(diphenyl)phosphine oxide

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Technology Process of [3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrole-1-yl]methyl(diphenyl)phosphine oxide

There total 3 articles about [3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrole-1-yl]methyl(diphenyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.3%

: 5276-94-8
(Aminomethyl)diphenylphosphine oxide

: 125971-96-2,125971-58-6
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

: 1342886-70-7
[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrole-1-yl]methyl(diphenyl)phosphine oxide

Guidance literature:: With Trimethylacetic acid; In toluene; at 20 ℃; for 48h; Reflux;

Reference yield:

: 719-80-2
Ethyl diphenylphosphinite

: 1342886-70-7
[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrole-1-yl]methyl(diphenyl)phosphine oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 48 h / 20 - 90 °C

2.1: hydrogen bromide / water / 15 h / 100 °C

2.2: pH 10 - 11

3.1: Trimethylacetic acid / toluene / 48 h / 20 °C / Reflux

With hydrogen bromide; Trimethylacetic acid; In water; toluene; 1.1: Arbuzov Reaction;

Reference yield:

: 4731-71-9
diphenyl(N-phthalimidomethyl)phosphine oxide

: 1342886-70-7
[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrole-1-yl]methyl(diphenyl)phosphine oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide / water / 15 h / 100 °C

1.2: pH 10 - 11

2.1: Trimethylacetic acid / toluene / 48 h / 20 °C / Reflux

With hydrogen bromide; Trimethylacetic acid; In water; toluene;