4-[(E)-10-(4-Aminomethyl-phenoxy)-dec-5-enyloxy]-benzylamine

Base Information

• Chemical Name: 4-[(E)-10-(4-Aminomethyl-phenoxy)-dec-5-enyloxy]-benzylamine
• CAS No.: 348081-97-0
• Molecular Formula: C₂₄H₃₄N₂O₂
• Molecular Weight: 382.546
• Mol file: 348081-97-0.mol

Synonyms:4-[(E)-10-(4-Aminomethyl-phenoxy)-dec-5-enyloxy]-benzylamine

Chemical Property of 4-[(E)-10-(4-Aminomethyl-phenoxy)-dec-5-enyloxy]-benzylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-[(E)-10-(4-Aminomethyl-phenoxy)-dec-5-enyloxy]-benzylamine

There total 6 articles about 4-[(E)-10-(4-Aminomethyl-phenoxy)-dec-5-enyloxy]-benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(4-{10-[4-(tert-butoxycarbonylamino-methyl)-phenoxy]-dec-5-enyloxy}-benzyl)-carbamic acid tert-butyl ester → 4-[(E)-10-(4-Aminomethyl-phenoxy)-dec-5-enyloxy]-benzylamine (348081-97-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1002/1521-3773(20010417)40:8<1538::AID-ANIE1538>3.0.CO;2-F

Reference yield:

5-Hexen-1-ol (821-41-0) → 4-[(E)-10-(4-Aminomethyl-phenoxy)-dec-5-enyloxy]-benzylamine (348081-97-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 59 percent / Ph₃P; DEAD / tetrahydrofuran / 0 °C

2: 94 percent / LiAlH₄ / tetrahydrofuran

3: 87 percent / NEt₃ / methanol

4: 78 percent / [Ru(=CHPh)(PCy₃)2Cl₂] / CH₂Cl₂ / 24 h / 20 °C

5: 93 percent / CF₃CO₂H / CH₂Cl₂

With lithium aluminium tetrahydride; Grubbs catalyst first generation; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/1521-3773(20010417)40:8<1538::AID-ANIE1538>3.0.CO;2-F

Reference yield:

4-cyanophenol (767-00-0) → 4-[(E)-10-(4-Aminomethyl-phenoxy)-dec-5-enyloxy]-benzylamine (348081-97-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 59 percent / Ph₃P; DEAD / tetrahydrofuran / 0 °C

2: 94 percent / LiAlH₄ / tetrahydrofuran

3: 87 percent / NEt₃ / methanol

4: 78 percent / [Ru(=CHPh)(PCy₃)2Cl₂] / CH₂Cl₂ / 24 h / 20 °C

5: 93 percent / CF₃CO₂H / CH₂Cl₂

With lithium aluminium tetrahydride; Grubbs catalyst first generation; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/1521-3773(20010417)40:8<1538::AID-ANIE1538>3.0.CO;2-F

upstream raw materials:

5-Hexen-1-ol

4-cyanophenol

(4-(hex-5-enyloxy)phenyl)methamine