Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester

Base Information

Chemical Name:Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester
CAS No.:125846-71-1
Molecular Formula:C₂₅H₃₄N₂O₆S
Molecular Weight:490.621
Hs Code.:

Synonyms:Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester

Suppliers and Price of Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester

There total 6 articles about Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2-dihydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester

: 125846-71-1
Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 10h; under 3750.3 Torr; Ambient temperature;
DOI:10.1021/jm00167a033

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 125846-71-1
Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / thionyl chloride / CH₂Cl₂ / 1 h / Heating

2: triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

3: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature

4: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

5: 2 h / 90 - 95 °C

6: H₂ / Pd/C / acetic acid / 10 h / 3750.3 Torr / Ambient temperature

With hydrogenchloride; thionyl chloride; potassium tert-butylate; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In dichloromethane; acetic acid;
DOI:10.1021/jm00167a033

Reference yield:

: 73942-87-7
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

: 125846-71-1
Methanesulfonic acid 4-(2-{[3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propyl]-methyl-amino}-ethyl)-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

2: 2 h / 90 - 95 °C

3: H₂ / Pd/C / acetic acid / 10 h / 3750.3 Torr / Ambient temperature

With potassium tert-butylate; hydrogen; palladium on activated charcoal; In acetic acid;
DOI:10.1021/jm00167a033