Thioacetic acid S-{4-[4-(4-acetylsulfanyl-phenylethynyl)-2-ethyl-phenylethynyl]-phenyl} ester

Base Information

Chemical Name:Thioacetic acid S-{4-[4-(4-acetylsulfanyl-phenylethynyl)-2-ethyl-phenylethynyl]-phenyl} ester
CAS No.:171005-37-1
Molecular Formula:C₂₈H₂₂O₂S₂
Molecular Weight:454.613
Hs Code.:

Synonyms:Thioacetic acid S-{4-[4-(4-acetylsulfanyl-phenylethynyl)-2-ethyl-phenylethynyl]-phenyl} ester

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Chemical Property of Thioacetic acid S-{4-[4-(4-acetylsulfanyl-phenylethynyl)-2-ethyl-phenylethynyl]-phenyl} ester

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Technology Process of Thioacetic acid S-{4-[4-(4-acetylsulfanyl-phenylethynyl)-2-ethyl-phenylethynyl]-phenyl} ester

There total 11 articles about Thioacetic acid S-{4-[4-(4-acetylsulfanyl-phenylethynyl)-2-ethyl-phenylethynyl]-phenyl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 69746-43-6
1-iodo-4-thioacetylbenzene

: 187870-22-0
2-Ethyl-1,4-diethynyl-benzene

: 171005-37-1
Thioacetic acid S-{4-[4-(4-acetylsulfanyl-phenylethynyl)-2-ethyl-phenylethynyl]-phenyl} ester

Guidance literature:: With copper(l) iodide; diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; for 24h;
DOI:10.1021/jo962336q

Reference yield:

: 121-89-1
3-Nitroacetophenone

: 171005-37-1
Thioacetic acid S-{4-[4-(4-acetylsulfanyl-phenylethynyl)-2-ethyl-phenylethynyl]-phenyl} ester

Guidance literature:: Multi-step reaction with 11 steps

1: 12.29 g / conc. HCl, H₂ / Pd/C / ethanol / 70 °C / 3102.9 Torr

2: 96 percent / 1 M NaOH / tetrahydrofuran / 2 h / Heating

3: AlCl₃ / CS₂ / 70 °C

4: 3 M KOH

5: aq. HCl, NaNO₂ / 0.5 h / 0 °C

6: K₂CO₃ / 0.5 h / 0 °C

8: 99 percent / MeI / 120 °C

9: 93 percent / Pd(dba)2, Ph₃P, CuI, i-Pr₂NH / tetrahydrofuran / 24 h

10: 88 percent / K₂CO₃ / methanol

11: 70 percent / Pd(dba)2, Ph₃P, CuI, i-Pr₂NH / tetrahydrofuran / 24 h

With hydrogenchloride; potassium hydroxide; sodium hydroxide; copper(l) iodide; aluminium trichloride; hydrogen; potassium carbonate; diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium nitrite; methyl iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; carbon disulfide; ethanol;
DOI:10.1021/jo962336q

Reference yield:

: 103029-25-0
4-amino-2-ethylacetophenone

: 171005-37-1
Thioacetic acid S-{4-[4-(4-acetylsulfanyl-phenylethynyl)-2-ethyl-phenylethynyl]-phenyl} ester

Guidance literature:: Multi-step reaction with 7 steps

1: aq. HCl, NaNO₂ / 0.5 h / 0 °C

2: K₂CO₃ / 0.5 h / 0 °C

4: 99 percent / MeI / 120 °C

5: 93 percent / Pd(dba)2, Ph₃P, CuI, i-Pr₂NH / tetrahydrofuran / 24 h

6: 88 percent / K₂CO₃ / methanol

7: 70 percent / Pd(dba)2, Ph₃P, CuI, i-Pr₂NH / tetrahydrofuran / 24 h

With hydrogenchloride; copper(l) iodide; potassium carbonate; diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium nitrite; methyl iodide; In tetrahydrofuran; methanol;
DOI:10.1021/jo962336q