5-(8-oxo-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7yl)-3-trifluoromethylpyridine-2-carbonitrile

Base Information

Chemical Name:5-(8-oxo-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7yl)-3-trifluoromethylpyridine-2-carbonitrile
CAS No.:956104-39-5
Molecular Formula:C₂₀H₁₅F₃N₄OS
Molecular Weight:416.427
Hs Code.:

Synonyms:5-(8-oxo-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7yl)-3-trifluoromethylpyridine-2-carbonitrile

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Chemical Property of 5-(8-oxo-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7yl)-3-trifluoromethylpyridine-2-carbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-(8-oxo-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7yl)-3-trifluoromethylpyridine-2-carbonitrile

There total 17 articles about 5-(8-oxo-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7yl)-3-trifluoromethylpyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 951753-87-0
5-isothiocyanato-3-(trifluoromethyl)pyridine-2-carbonitrile

: N-cyclobutyl-4-methylaniline

: 956104-39-5
5-(8-oxo-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7yl)-3-trifluoromethylpyridine-2-carbonitrile

Guidance literature:: With hydrogenchloride; In methanol; water; at 20 ℃; for 24h; Reflux;

Reference yield: 60.0%

: 915086-37-2
1-(4-methylphenyl)aminocyclobutanecarbonitrile

: 951753-87-0
5-isothiocyanato-3-(trifluoromethyl)pyridine-2-carbonitrile

: 956104-39-5
5-(8-oxo-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7yl)-3-trifluoromethylpyridine-2-carbonitrile

Guidance literature:: 1-(4-methylphenyl)aminocyclobutanecarbonitrile; 5-isothiocyanato-3-(trifluoromethyl)pyridine-2-carbonitrile; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With hydrogenchloride; water; In methanol; N,N-dimethyl-formamide; for 2h; Reflux;

Reference yield:

: 3796-23-4
3-(trifluoromethyl)pyridine

: 956104-39-5
5-(8-oxo-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7yl)-3-trifluoromethylpyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: methyltrioxorhenium(VII); dihydrogen peroxide / dichloromethane / 5 h / 20 °C

1.2: 1 h

2.1: triethylamine / acetonitrile / 24 h / 20 °C

3.1: trifluoroacetic acid; tetramethylammonium nitrate / 48 - 60 °C / Sealed tube

4.1: iron; acetic acid / ethyl acetate / 15 h

5.1: water / 2 h

6.1: hydrogenchloride / water; methanol / 24 h / 20 °C / Reflux

With hydrogenchloride; dihydrogen peroxide; tetramethylammonium nitrate; methyltrioxorhenium(VII); iron; acetic acid; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate; acetonitrile;