diethyl 4-(4-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:diethyl 4-(4-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:1424371-06-1
Molecular Formula:C₂₉H₂₉ClN₂O₅
Molecular Weight:521.013
Hs Code.:

Synonyms:diethyl 4-(4-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of diethyl 4-(4-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of diethyl 4-(4-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 4 articles about diethyl 4-(4-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 102878-18-2
2,4-dichloro-6-methyl-quinoline

: 10354-30-0
4-(4-hydroxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

: 1424371-06-1
diethyl 4-(4-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 48h; regioselective reaction;
DOI:10.1007/s11164-013-1085-4

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1424371-06-1
diethyl 4-(4-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / ethanol

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C

With ammonium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 1: |Hantzsch Dihydropyridine Synthesis;
DOI:10.1007/s11164-013-1085-4

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1424371-06-1
diethyl 4-(4-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 5 h

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C

With potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1007/s11164-013-1085-4