benzyl (2S)-3-[[(2S)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate

Base Information

Chemical Name:benzyl (2S)-3-[[(2S)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate
CAS No.:947189-94-8
Molecular Formula:C₃₃H₃₇N₃O₇
Molecular Weight:587.673
Hs Code.:

Synonyms:benzyl (2S)-3-[[(2S)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate

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Chemical Property of benzyl (2S)-3-[[(2S)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate

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Technology Process of benzyl (2S)-3-[[(2S)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate

There total 3 articles about benzyl (2S)-3-[[(2S)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: benzyl (2S)-3-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino) propanoate hydrochloride

: 947189-94-8
benzyl (2S)-3-[[(2S)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate

Guidance literature:: benzyl (2S)-3-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino) propanoate hydrochloride; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

L-N-Boc-Ala; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 668985-56-6
Fmoc-L-Dap(Boc)-OBn

: benzyl (2S)-3-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino) propanoate hydrochloride

: 947189-94-8
benzyl (2S)-3-[[(2S)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 48h;
DOI:10.1021/ja068573k

Reference yield:

: 668985-56-6
Fmoc-L-Dap(Boc)-OBn

: 947189-94-8
benzyl (2S)-3-[[(2S)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / ethyl acetate / 1 h / 25 °C

2: NaHCO₃; 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide; CH₂Cl₂ / 48 h / 0 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja068573k