E/Z-1-{4-[2-({2-[2-(2-aminooxyethoxy)ethoxy]ethyl}methylamino)ethoxy]phenyl}-1-(4-hydroxyphenyl)-2-phenylbutene

Base Information

• Chemical Name: E/Z-1-{4-[2-({2-[2-(2-aminooxyethoxy)ethoxy]ethyl}methylamino)ethoxy]phenyl}-1-(4-hydroxyphenyl)-2-phenylbutene
• CAS No.: 850256-34-7
• Molecular Formula: C₃₁H₄₀N₂O₅
• Molecular Weight: 520.669

Synonyms:E/Z-1-{4-[2-({2-[2-(2-aminooxyethoxy)ethoxy]ethyl}methylamino)ethoxy]phenyl}-1-(4-hydroxyphenyl)-2-phenylbutene

Chemical Property of E/Z-1-{4-[2-({2-[2-(2-aminooxyethoxy)ethoxy]ethyl}methylamino)ethoxy]phenyl}-1-(4-hydroxyphenyl)-2-phenylbutene

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of E/Z-1-{4-[2-({2-[2-(2-aminooxyethoxy)ethoxy]ethyl}methylamino)ethoxy]phenyl}-1-(4-hydroxyphenyl)-2-phenylbutene

There total 10 articles about E/Z-1-{4-[2-({2-[2-(2-aminooxyethoxy)ethoxy]ethyl}methylamino)ethoxy]phenyl}-1-(4-hydroxyphenyl)-2-phenylbutene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

E/Z-4-[2-(2-{2-[(2-{4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenoxy}ethyl)methylamino]ethoxy}ethoxy)ethoxy]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione → E/Z-1-{4-[2-({2-[2-(2-aminooxyethoxy)ethoxy]ethyl}methylamino)ethoxy]phenyl}-1-(4-hydroxyphenyl)-2-phenylbutene (850256-34-7)

Guidance literature:

With hydrazine hydrate; In ethanol; at 60 ℃; for 2h;

DOI:10.1021/jm030352r

Reference yield:

4-(methoxymethoxy)-4'-methoxybenzophenone (115499-97-3) → E/Z-1-{4-[2-({2-[2-(2-aminooxyethoxy)ethoxy]ethyl}methylamino)ethoxy]phenyl}-1-(4-hydroxyphenyl)-2-phenylbutene (850256-34-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 97 percent / n-BuLi; t-BuOK; TMEDA

2.1: 93 percent / aq. HCl

3.1: 90 percent / (n-Bu)4NHSO₄; NaOH

4.1: 57 percent / BBr₃

5.1: DIPEA

5.2: hydrazine

With hydrogenchloride; sodium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; potassium tert-butylate; tetra(n-butyl)ammonium hydrogensulfate; boron tribromide; N-ethyl-N,N-diisopropylamine;

DOI:10.1021/jm049496b

Reference yield:

E/Z-1-[4-(2-bromoethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenylbutene (147323-02-2) → E/Z-1-{4-[2-({2-[2-(2-aminooxyethoxy)ethoxy]ethyl}methylamino)ethoxy]phenyl}-1-(4-hydroxyphenyl)-2-phenylbutene (850256-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: DIPEA

1.2: hydrazine

With N-ethyl-N,N-diisopropylamine;

DOI:10.1021/jm049496b

upstream raw materials:

(E/Z)-4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol

E/Z-1-[4-(2-bromoethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenylbutene

4-(methoxymethoxy)-4'-methoxybenzophenone

E/Z-1-(4-hydroxyphenyl)-1-(4-methoxyphenyl)-2-phenylbutene

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